Degrade to survive: the intricate world of piroplasmid proteases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00574491" target="_blank" >RIV/60077344:_____/23:00574491 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/23:43907335

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1471492223001186?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1471492223001186?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pt.2023.04.010" target="_blank" >10.1016/j.pt.2023.04.010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Degrade to survive: the intricate world of piroplasmid proteases

Popis výsledku v původním jazyce

Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key proteases, using inhibitors or antibodies, hinders piroplasmid growth, highlighting their potential usefulness in drug therapies and vaccine development. A better understanding of the functional significance of these enzymes will contribute to the development of improved control measures for the devastating animal and human diseases caused by these pathogens.

Název v anglickém jazyce

Degrade to survive: the intricate world of piroplasmid proteases

Popis výsledku anglicky

Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key proteases, using inhibitors or antibodies, hinders piroplasmid growth, highlighting their potential usefulness in drug therapies and vaccine development. A better understanding of the functional significance of these enzymes will contribute to the development of improved control measures for the devastating animal and human diseases caused by these pathogens.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Trends in Parasitology

ISSN

1471-4922

e-ISSN

1471-5007

Svazek periodika

39

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

15

Strana od-do

532-546

Kód UT WoS článku

001027544600001

EID výsledku v databázi Scopus

2-s2.0-85160750621