Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00574500" target="_blank" >RIV/60077344:_____/23:00574500 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/23:43907930

Výsledek na webu

<a href="https://journals.biologists.com/dev/article/150/10/dev201186/310536/Female-reproductive-dormancy-in-Drosophila-is" target="_blank" >https://journals.biologists.com/dev/article/150/10/dev201186/310536/Female-reproductive-dormancy-in-Drosophila-is</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1242/dev.201186" target="_blank" >10.1242/dev.201186</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum

Popis výsledku v původním jazyce

Female insects can enter reproductive diapause, a state of suspended egg development, to conserve energy under adverse environments. In many insects, including the fruit fly, Drosophila melanogaster, reproductive diapause, also frequently called reproductive dormancy, is induced under low-temperature and short-day conditions by the downregulation of juvenile hormone (JH) biosynthesis in the corpus allatum (CA). In this study, we demonstrate that neuropeptide Diuretic hormone 31 (DH31) produced by brain neurons that project into the CA plays an essential role in regulating reproductive dormancy by suppressing JH biosynthesis in adult D. melanogaster. The CA expresses the gene encoding the DH31 receptor, which is required for DH31-triggered elevation of intracellular cAMP in the CA. Knocking down Dh31 in these CA-projecting neurons or DH31 receptor in the CA suppresses the decrease of JH titer, normally observed under dormancy-inducing conditions, leading to abnormal yolk accumulation in the ovaries. Our findings provide the first molecular genetic evidence demonstrating that CA-projecting peptidergic neurons play an essential role in regulating reproductive dormancy by suppressing JH biosynthesis.

Název v anglickém jazyce

Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum

Popis výsledku anglicky

Female insects can enter reproductive diapause, a state of suspended egg development, to conserve energy under adverse environments. In many insects, including the fruit fly, Drosophila melanogaster, reproductive diapause, also frequently called reproductive dormancy, is induced under low-temperature and short-day conditions by the downregulation of juvenile hormone (JH) biosynthesis in the corpus allatum (CA). In this study, we demonstrate that neuropeptide Diuretic hormone 31 (DH31) produced by brain neurons that project into the CA plays an essential role in regulating reproductive dormancy by suppressing JH biosynthesis in adult D. melanogaster. The CA expresses the gene encoding the DH31 receptor, which is required for DH31-triggered elevation of intracellular cAMP in the CA. Knocking down Dh31 in these CA-projecting neurons or DH31 receptor in the CA suppresses the decrease of JH titer, normally observed under dormancy-inducing conditions, leading to abnormal yolk accumulation in the ovaries. Our findings provide the first molecular genetic evidence demonstrating that CA-projecting peptidergic neurons play an essential role in regulating reproductive dormancy by suppressing JH biosynthesis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/GA22-21244S" target="_blank" >GA22-21244S: Výzkum regulace vývoje a reprodukce řízené juvenilním hormonem (JH) u komárů, s využitím mutantů, kteří neprodukují JH</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Development

ISSN

0950-1991

e-ISSN

1477-9129

Svazek periodika

150

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

dev201186

Kód UT WoS článku

001013373500002

EID výsledku v databázi Scopus

2-s2.0-85159836236