Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00580593" target="_blank" >RIV/60077344:_____/23:00580593 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/23:43906687 RIV/61988987:17310/23:A2402N63

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/brv.12988" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/brv.12988</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/brv.12988" target="_blank" >10.1111/brv.12988</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes

Popis výsledku v původním jazyce

Genetic variation is the major mechanism behind adaptation and evolutionary change. As most proteins operate through interactions with other proteins, changes in protein complex composition and subunit sequence provide potentially new functions. Comparative genomics can reveal expansions, losses and sequence divergence within protein-coding genes, but in silico analysis cannot detect subunit substitutions or replacements of entire protein complexes. Insights into these fundamental evolutionary processes require broad and extensive comparative analyses, from both in silico and experimental evidence. Here, we combine data from both approaches and consider the gamut of possible protein complex compositional changes that arise during evolution, citing examples of complete conservation to partial and total replacement by functional analogues. We focus in part on complexes in trypanosomes as they represent one of the better studied non-animal/non-fungal lineages, but extend insights across the eukaryotes by extensive comparative genomic analysis. We argue that gene loss plays an important role in diversification of protein complexes and hence enhancement of eukaryotic diversity.

Název v anglickém jazyce

Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes

Popis výsledku anglicky

Genetic variation is the major mechanism behind adaptation and evolutionary change. As most proteins operate through interactions with other proteins, changes in protein complex composition and subunit sequence provide potentially new functions. Comparative genomics can reveal expansions, losses and sequence divergence within protein-coding genes, but in silico analysis cannot detect subunit substitutions or replacements of entire protein complexes. Insights into these fundamental evolutionary processes require broad and extensive comparative analyses, from both in silico and experimental evidence. Here, we combine data from both approaches and consider the gamut of possible protein complex compositional changes that arise during evolution, citing examples of complete conservation to partial and total replacement by functional analogues. We focus in part on complexes in trypanosomes as they represent one of the better studied non-animal/non-fungal lineages, but extend insights across the eukaryotes by extensive comparative genomic analysis. We argue that gene loss plays an important role in diversification of protein complexes and hence enhancement of eukaryotic diversity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biological Reviews

ISSN

1464-7931

e-ISSN

1469-185X

Svazek periodika

98

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

18

Strana od-do

1910-1927

Kód UT WoS článku

001010386900001

EID výsledku v databázi Scopus

2-s2.0-85162095919