Dysregulation of mitochondrial bioenergetics leads to elevated ROS levels and promotes programmed developmental progression of Trypanosoma brucei

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00583119" target="_blank" >RIV/60077344:_____/23:00583119 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/eci.13992" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/eci.13992</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Dysregulation of mitochondrial bioenergetics leads to elevated ROS levels and promotes programmed developmental progression of Trypanosoma brucei

Popis výsledku v původním jazyce

Background: In the last decade, the importance of mitochondrially derived reactive oxygen species (OS) as signals in intracellular communication has been sealed. These though-to-be harmful molecules influence cellular faith decisions and can drive cells towards proliferation, apoptosis or differentiation. The OS are mainly generated as by-products during the process of oxidative phosphorylation (OXPHOS), which is completed by FoF1-ATP synthase with the formation of ATP. In trypanosomes, unicellular parasites undergoing programmed life cycle development, the cellular differentiation is linked to increased mitochondrial metabolic activity and OS production.

Název v anglickém jazyce

Dysregulation of mitochondrial bioenergetics leads to elevated ROS levels and promotes programmed developmental progression of Trypanosoma brucei

Popis výsledku anglicky

Background: In the last decade, the importance of mitochondrially derived reactive oxygen species (OS) as signals in intracellular communication has been sealed. These though-to-be harmful molecules influence cellular faith decisions and can drive cells towards proliferation, apoptosis or differentiation. The OS are mainly generated as by-products during the process of oxidative phosphorylation (OXPHOS), which is completed by FoF1-ATP synthase with the formation of ATP. In trypanosomes, unicellular parasites undergoing programmed life cycle development, the cellular differentiation is linked to increased mitochondrial metabolic activity and OS production.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10606 - Microbiology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů