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Advances in vertebrate (cyto)genomics shed new light on fish compositional genome evolution

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00583820" target="_blank" >RIV/60077344:_____/23:00583820 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/60076658:12310/23:43906428 RIV/62690094:18450/23:50020270 RIV/62690094:18470/23:50020270

  • Výsledek na webu

    <a href="https://doi.org/10.3390/genes14020244" target="_blank" >https://doi.org/10.3390/genes14020244</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/genes14020244" target="_blank" >10.3390/genes14020244</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Advances in vertebrate (cyto)genomics shed new light on fish compositional genome evolution

  • Popis výsledku v původním jazyce

    Cytogenetic and compositional studies considered fish genomes rather poor in guanine-cytosine content (GC%) because of a putative 'sharp increase in genic GC% during the evolution of higher vertebrates'. However, the available genomic data have not been exploited to confirm this viewpoint. In contrast, further misunderstandings in GC%, mostly of fish genomes, originated from a misapprehension of the current flood of data. Utilizing public databases, we calculated the GC% in animal genomes of three different, technically well-established fractions: DNA (entire genome), cDNA (complementary DNA), and cds (exons). Our results across chordates help set borders of GC% values that are still incorrect in literature and show: (i) fish in their immense diversity possess comparably GC-rich (or even GC-richer) genomes as higher vertebrates, and fish exons are GC-enriched among vertebrates., (ii) animal genomes generally show a GC-enrichment from the DNA, over cDNA, to the cds level (i.e., not only the higher vertebrates)., (iii) fish and invertebrates show a broad(er) inter-quartile range in GC%, while avian and mammalian genomes are more constrained in their GC%. These results indicate no sharp increase in the GC% of genes during the transition to higher vertebrates, as stated and numerously repeated before. We present our results in 2D and 3D space to explore the compositional genome landscape and prepared an online platform to explore the AT/GC compositional genome evolution.

  • Název v anglickém jazyce

    Advances in vertebrate (cyto)genomics shed new light on fish compositional genome evolution

  • Popis výsledku anglicky

    Cytogenetic and compositional studies considered fish genomes rather poor in guanine-cytosine content (GC%) because of a putative 'sharp increase in genic GC% during the evolution of higher vertebrates'. However, the available genomic data have not been exploited to confirm this viewpoint. In contrast, further misunderstandings in GC%, mostly of fish genomes, originated from a misapprehension of the current flood of data. Utilizing public databases, we calculated the GC% in animal genomes of three different, technically well-established fractions: DNA (entire genome), cDNA (complementary DNA), and cds (exons). Our results across chordates help set borders of GC% values that are still incorrect in literature and show: (i) fish in their immense diversity possess comparably GC-rich (or even GC-richer) genomes as higher vertebrates, and fish exons are GC-enriched among vertebrates., (ii) animal genomes generally show a GC-enrichment from the DNA, over cDNA, to the cds level (i.e., not only the higher vertebrates)., (iii) fish and invertebrates show a broad(er) inter-quartile range in GC%, while avian and mammalian genomes are more constrained in their GC%. These results indicate no sharp increase in the GC% of genes during the transition to higher vertebrates, as stated and numerously repeated before. We present our results in 2D and 3D space to explore the compositional genome landscape and prepared an online platform to explore the AT/GC compositional genome evolution.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    10620 - Other biological topics

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2023

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Genes

  • ISSN

    2073-4425

  • e-ISSN

    2073-4425

  • Svazek periodika

    14

  • Číslo periodika v rámci svazku

    2

  • Stát vydavatele periodika

    CH - Švýcarská konfederace

  • Počet stran výsledku

    16

  • Strana od-do

    244

  • Kód UT WoS článku

    000939064500001

  • EID výsledku v databázi Scopus

    2-s2.0-85148873460