High-throughput sequencing of Strongyloides stercoralis a fatal disseminated infection in a dog

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00586234" target="_blank" >RIV/60077344:_____/24:00586234 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081766:_____/24:00586234 RIV/60460709:41210/24:98595 RIV/00216224:14310/24:00137128 RIV/62157124:16170/24:43881170

Výsledek na webu

<a href="https://www.cambridge.org/core/journals/parasitology/article/highthroughput-sequencing-of-strongyloides-stercoralis-a-fatal-disseminated-infection-in-a-dog/E085E2C44E784F4EEA6DAEFF5E23199B" target="_blank" >https://www.cambridge.org/core/journals/parasitology/article/highthroughput-sequencing-of-strongyloides-stercoralis-a-fatal-disseminated-infection-in-a-dog/E085E2C44E784F4EEA6DAEFF5E23199B</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1017/S0031182024000568" target="_blank" >10.1017/S0031182024000568</a>

Jazyk výsledku

angličtina

Název v původním jazyce

High-throughput sequencing of Strongyloides stercoralis a fatal disseminated infection in a dog

Popis výsledku v původním jazyce

The rhabditid nematode Strongyloides stercoralis is known worldwide as the causative agent of strongyloidiasis in humans. In addition to public health concerns, S. stercoralis also infects dogs, that represent a possible reservoir for potentially zoonotic transmissions. We describe the first confirmed case of fatal disseminated infection in a dog in the Czech Republic. The microscopic and histological results were supported by a complex genotyping approach. Using high-throughput sequencing of the hypervariable region (HVR-IV) of 18S rDNA and Sanger sequencing of the partial cytochrome c oxidase subunit 1 gene (cox1), the potentially zoonotic haplotype/lineage A of S. stercoralis was confirmed, while the solely canine haplotype/lineage B was not found. The development of the disease is mainly associated with immunodeficiency, and in this case, it was triggered by inappropriate treatment, in particular the use of corticosteroids.

Název v anglickém jazyce

High-throughput sequencing of Strongyloides stercoralis a fatal disseminated infection in a dog

Popis výsledku anglicky

The rhabditid nematode Strongyloides stercoralis is known worldwide as the causative agent of strongyloidiasis in humans. In addition to public health concerns, S. stercoralis also infects dogs, that represent a possible reservoir for potentially zoonotic transmissions. We describe the first confirmed case of fatal disseminated infection in a dog in the Czech Republic. The microscopic and histological results were supported by a complex genotyping approach. Using high-throughput sequencing of the hypervariable region (HVR-IV) of 18S rDNA and Sanger sequencing of the partial cytochrome c oxidase subunit 1 gene (cox1), the potentially zoonotic haplotype/lineage A of S. stercoralis was confirmed, while the solely canine haplotype/lineage B was not found. The development of the disease is mainly associated with immunodeficiency, and in this case, it was triggered by inappropriate treatment, in particular the use of corticosteroids.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Parasitology

ISSN

0031-1820

e-ISSN

1469-8161

Svazek periodika

151

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

587-593

Kód UT WoS článku

001232015200001

EID výsledku v databázi Scopus

2-s2.0-85192692601