Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00600338" target="_blank" >RIV/60077344:_____/24:00600338 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/24:00600338

Výsledek na webu

<a href="https://doi.org/10.1016/j.bbabio.2024.149465" target="_blank" >https://doi.org/10.1016/j.bbabio.2024.149465</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome

Popis výsledku v původním jazyce

Obesity and its associated comorbidities, particularly metabolic syndrome, are a growing problem in developed societies. Due to its polygenic nature, the genetic component of metabolic syndrome is only slowly being elucidated. Common mitochondrial DNA (mtDNA) sequence variants have been associated with late-onset human diseases, including cardiovascular disease or type 2 diabetes mellitus, and may therefore be relevant players in the genetics of metabolic syndrome. Our work has demonstrated that physiological sequence variation in mitochondrial rRNA may be a relevant underlying factor in the progression of metabolic syndrome.

Název v anglickém jazyce

Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome

Popis výsledku anglicky

Obesity and its associated comorbidities, particularly metabolic syndrome, are a growing problem in developed societies. Due to its polygenic nature, the genetic component of metabolic syndrome is only slowly being elucidated. Common mitochondrial DNA (mtDNA) sequence variants have been associated with late-onset human diseases, including cardiovascular disease or type 2 diabetes mellitus, and may therefore be relevant players in the genetics of metabolic syndrome. Our work has demonstrated that physiological sequence variation in mitochondrial rRNA may be a relevant underlying factor in the progression of metabolic syndrome.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/LX22NPO5104" target="_blank" >LX22NPO5104: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů