You can go your own way: The targeting signals of trypanosomatid parasites

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00638026" target="_blank" >RIV/60077344:_____/25:00638026 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/25:43909851

Výsledek na webu

<a href="https://doi.org/10.1371/journal.ppat.1013326" target="_blank" >https://doi.org/10.1371/journal.ppat.1013326</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.ppat.1013326" target="_blank" >10.1371/journal.ppat.1013326</a>

Jazyk výsledku

angličtina

Název v původním jazyce

You can go your own way: The targeting signals of trypanosomatid parasites

Popis výsledku v původním jazyce

Targeting and directing cytosol-synthesized proteins into organelles and cellular compartments constitutes a universal eukaryotic challenge. The discovery that specific peptide sequences are responsible for this localization not only earned a Nobel prize, but also provided a powerful tool for investigating eukaryotic evolution and diversification [1]. While the term ‘targeting signal’ encompasses a broad range of sequences with varying properties, here we define them as sequences—or a set of sequences—that are both necessary and sufficient to ensure a protein reaches its correct cellular localization. Parasitic trypanosomatids, represented primarily by model protist Trypanosoma brucei, constitute the most thoroughly investigated eukaryotes in this regard outside of opisthokonts and plants. Here we provide a protistan perspective on the targeting signals, both innovated and derived, employed by trypanosomatid flagellates for this purpose (Fig 1).

Název v anglickém jazyce

You can go your own way: The targeting signals of trypanosomatid parasites

Popis výsledku anglicky

Targeting and directing cytosol-synthesized proteins into organelles and cellular compartments constitutes a universal eukaryotic challenge. The discovery that specific peptide sequences are responsible for this localization not only earned a Nobel prize, but also provided a powerful tool for investigating eukaryotic evolution and diversification [1]. While the term ‘targeting signal’ encompasses a broad range of sequences with varying properties, here we define them as sequences—or a set of sequences—that are both necessary and sufficient to ensure a protein reaches its correct cellular localization. Parasitic trypanosomatids, represented primarily by model protist Trypanosoma brucei, constitute the most thoroughly investigated eukaryotes in this regard outside of opisthokonts and plants. Here we provide a protistan perspective on the targeting signals, both innovated and derived, employed by trypanosomatid flagellates for this purpose (Fig 1).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/GX23-06479X" target="_blank" >GX23-06479X: Co vlastně dělají nejběžnější bílkoviny v oceánu?</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS Pathogens

ISSN

1553-7366

e-ISSN

1553-7374

Svazek periodika

21

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

e1013326

Kód UT WoS článku

001542579800006

EID výsledku v databázi Scopus

2-s2.0-105012179314