Translon: a single term for translated regions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00643212" target="_blank" >RIV/60077344:_____/25:00643212 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/25:00643212 RIV/60076658:12310/25:43910592 RIV/61988987:17310/25:A2603CVT

Výsledek na webu

<a href="https://www.nature.com/articles/s41592-025-02810-3" target="_blank" >https://www.nature.com/articles/s41592-025-02810-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41592-025-02810-3" target="_blank" >10.1038/s41592-025-02810-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Translon: a single term for translated regions

Popis výsledku v původním jazyce

During translation, ribosomes synthesize polypeptides using RNA molecules as templates. All cellular proteins are products of translation, and the identification of protein-coding regions is the primary goal of genome annotation. Beyond protein synthesis, translation has long been known to have regulatory functions independent of its products1,2. However, only with the advent of ribosome profiling was the broad scale and complexity of translated regions fully appreciated. Recent interest in pervasive translation has exposed a lack of general terminology for translated regions that does not depend on the properties of their products or their sequence. In the absence of such terminology, a range of inconsistently defined terms are used to describe them. These terms are typically variations on ‘open reading frame’ (ORF) — for example, non-canonical ORF (ncORF), RiboSeq ORF, alternative ORF (altORF), translated ORF (tORF), small ORF (smORF), short ORF (sORF) and others. Such terms largely overlap and redundantly describe the same core concept: that the region in question isntranslated.n

Název v anglickém jazyce

Translon: a single term for translated regions

Popis výsledku anglicky

During translation, ribosomes synthesize polypeptides using RNA molecules as templates. All cellular proteins are products of translation, and the identification of protein-coding regions is the primary goal of genome annotation. Beyond protein synthesis, translation has long been known to have regulatory functions independent of its products1,2. However, only with the advent of ribosome profiling was the broad scale and complexity of translated regions fully appreciated. Recent interest in pervasive translation has exposed a lack of general terminology for translated regions that does not depend on the properties of their products or their sequence. In the absence of such terminology, a range of inconsistently defined terms are used to describe them. These terms are typically variations on ‘open reading frame’ (ORF) — for example, non-canonical ORF (ncORF), RiboSeq ORF, alternative ORF (altORF), translated ORF (tORF), small ORF (smORF), short ORF (sORF) and others. Such terms largely overlap and redundantly describe the same core concept: that the region in question isntranslated.n

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Methods

ISSN

1548-7091

e-ISSN

1548-7105

Svazek periodika

22

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

2002-2006

Kód UT WoS článku

001637758100001

EID výsledku v databázi Scopus

2-s2.0-105018346556