Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00645063" target="_blank" >RIV/60077344:_____/25:00645063 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378050:_____/25:00645063 RIV/00216224:14310/25:00144627 RIV/00027162:_____/25:N0000140

Výsledek na webu

<a href="https://doi.org/10.1099/jgv.0.002161" target="_blank" >https://doi.org/10.1099/jgv.0.002161</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1099/jgv.0.002161" target="_blank" >10.1099/jgv.0.002161</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice

Popis výsledku v původním jazyce

Obesity is a growing global health concern with profound effects on immune function and vaccine efficacy. This study investigated the impact of obesity on immune responses to tick-borne encephalitis virus (TBEV) vaccination and infection using a mouse model. Mice on a high-fat diet (HFD) exhibited increased body weight, fat mass and a pre-diabetic state compared to standard chow diet (SCD) controls. After vaccination with the TBEV vaccine (Encepur), HFD mice showed significantly lower TBEV-specific IgG titres and neutralizing antibody levels compared to SCD mice. Splenocyte counts per organ mass were significantly higher in vaccinated SCD mice compared to their HFD counterparts, correlating with the elevated IgG titres observed in the SCD group. These results underscore the critical role of diet in shaping the immune response and vaccine efficacy. Following TBEV infection, HFD mice did not display increased disease severity or elevated viral titres in the serum, spleen or brain relative to SCD controls, indicating that obesity did not exacerbate viral replication or dissemination. However, a sex-dependent effect of obesity on the humoral immune response was observed. Male HFD mice produced antibody titres comparable to their SCD counterparts, suggesting minimal impact of obesity on their immune response. In contrast, female HFD mice exhibited significant impairments in TBEV-specific IgG and neutralizing antibody production compared to female SCD mice, as well as both male HFD and male SCD groups. These findings highlight a complex interplay between obesity, sex and immune function, with obesity disproportionately impairing the immune response after TBEV vaccination and infection.

Název v anglickém jazyce

Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice

Popis výsledku anglicky

Obesity is a growing global health concern with profound effects on immune function and vaccine efficacy. This study investigated the impact of obesity on immune responses to tick-borne encephalitis virus (TBEV) vaccination and infection using a mouse model. Mice on a high-fat diet (HFD) exhibited increased body weight, fat mass and a pre-diabetic state compared to standard chow diet (SCD) controls. After vaccination with the TBEV vaccine (Encepur), HFD mice showed significantly lower TBEV-specific IgG titres and neutralizing antibody levels compared to SCD mice. Splenocyte counts per organ mass were significantly higher in vaccinated SCD mice compared to their HFD counterparts, correlating with the elevated IgG titres observed in the SCD group. These results underscore the critical role of diet in shaping the immune response and vaccine efficacy. Following TBEV infection, HFD mice did not display increased disease severity or elevated viral titres in the serum, spleen or brain relative to SCD controls, indicating that obesity did not exacerbate viral replication or dissemination. However, a sex-dependent effect of obesity on the humoral immune response was observed. Male HFD mice produced antibody titres comparable to their SCD counterparts, suggesting minimal impact of obesity on their immune response. In contrast, female HFD mice exhibited significant impairments in TBEV-specific IgG and neutralizing antibody production compared to female SCD mice, as well as both male HFD and male SCD groups. These findings highlight a complex interplay between obesity, sex and immune function, with obesity disproportionately impairing the immune response after TBEV vaccination and infection.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10607 - Virology

Projekt

<a href="/cs/project/GA23-07160S" target="_blank" >GA23-07160S: Molekulární patogeneze alimentární infekce virem klíšťové encefalitidy.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of General Virology

ISSN

0022-1317

e-ISSN

1465-2099

Svazek periodika

106

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

002161

Kód UT WoS článku

001622972000002

EID výsledku v databázi Scopus

2-s2.0-105017937395