Mozaikový původ metabolické dráhy pro syntézu hemu u fotosyntetických eukaryot

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077409%3A_____%2F05%3A00025524" target="_blank" >RIV/60077409:_____/05:00025524 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Mosaic origin of the heme biosynthesis pathway in photosynthetic eukaryotes

Popis výsledku v původním jazyce

Heme biosynthesis is one of the most essential metabolic pathways. We have compared the heme pathway in diatoms and red algae to those of plants and heterotrophic eukaryotes. Phylogenetic analyses showed the mosaic character of this pathway in photosynthetic eukaryotes. Although most of the algal and plant enzymes showed the expected plastid origin, at least porphobilinogen deaminase appears to have a mitochondrial origin. Another enzyme, glutamyl-tRNA synthase, originated in eukaryotic nucleus. All theplastid-targeted sequences consistently form a common cluster, which suggests that genes were transferred from the primary endosymbiont to the primary host nucleus shortly after the primary endosymbiotic event, or were replaced with genes from other sources. The one striking exception to this pattern is ferrochelatase. In this case, two red algal sequences do not cluster either with the other plastid or cyanobacterial sequences, and appears to have a proteobacterial origin.

Název v anglickém jazyce

Mosaic origin of the heme biosynthesis pathway in photosynthetic eukaryotes

Popis výsledku anglicky

Heme biosynthesis is one of the most essential metabolic pathways. We have compared the heme pathway in diatoms and red algae to those of plants and heterotrophic eukaryotes. Phylogenetic analyses showed the mosaic character of this pathway in photosynthetic eukaryotes. Although most of the algal and plant enzymes showed the expected plastid origin, at least porphobilinogen deaminase appears to have a mitochondrial origin. Another enzyme, glutamyl-tRNA synthase, originated in eukaryotic nucleus. All theplastid-targeted sequences consistently form a common cluster, which suggests that genes were transferred from the primary endosymbiont to the primary host nucleus shortly after the primary endosymbiotic event, or were replaced with genes from other sources. The one striking exception to this pattern is ferrochelatase. In this case, two red algal sequences do not cluster either with the other plastid or cyanobacterial sequences, and appears to have a proteobacterial origin.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/IAA500220502" target="_blank" >IAA500220502: Evoluce metabolických drah v komplexním plastidu rozsivky Thalassiosira pseudonana</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Biology and Evolution

ISSN

0737-4038

e-ISSN

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Svazek periodika

22

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

2343-2353

Kód UT WoS článku

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EID výsledku v databázi Scopus

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