Therapeutic induction of programmed cell death

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Therapeutic induction of programmed cell death

Popis výsledku v původním jazyce

Cells and multicellular organisms share the ability to activate an internal death program known as apoptosis. Apoptosis theory, developed over the last 20 years, has challenged conceptual thinking in all aspects of cell biology. In cancer, the increase in the tumor burden can be regarded as the result of too much growth and too little death of the tumor cells. Therefore, the aim of chemotherapy and radiotherapy is to block proliferation and to enhance cell death. One of the major signaling pathways initiated by DNA damage and other cytotoxic stresses involves the induction of TP53 protein. Via induction of TP53, DNA damage can induce growth arrest or programmed cell death in many cell types. This induction response appears to be a major determinant ofresponses to chemotherapy in certain tumor types, such as those derived from lymphoid cells or germ cells. Mutation or loss of TP53 genes in hematopoietic malignancies appears to correlate well with poor prognosis. The mitochondria play k

Název v anglickém jazyce

Therapeutic induction of programmed cell death

Popis výsledku anglicky

Cells and multicellular organisms share the ability to activate an internal death program known as apoptosis. Apoptosis theory, developed over the last 20 years, has challenged conceptual thinking in all aspects of cell biology. In cancer, the increase in the tumor burden can be regarded as the result of too much growth and too little death of the tumor cells. Therefore, the aim of chemotherapy and radiotherapy is to block proliferation and to enhance cell death. One of the major signaling pathways initiated by DNA damage and other cytotoxic stresses involves the induction of TP53 protein. Via induction of TP53, DNA damage can induce growth arrest or programmed cell death in many cell types. This induction response appears to be a major determinant ofresponses to chemotherapy in certain tumor types, such as those derived from lymphoid cells or germ cells. Mutation or loss of TP53 genes in hematopoietic malignancies appears to correlate well with poor prognosis. The mitochondria play k

Druh

C - Kapitola v odborné knize

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2000

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Cells II

ISBN

80-7232-120-X

Počet stran výsledku

7

Strana od-do

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Počet stran knihy

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Název nakladatele

Kopp

Místo vydání

České Budějovice

Kód UT WoS kapitoly

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