The long term effects of low-level sarin inhalation exposure on cognitive functions in rats

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The long term effects of low-level sarin inhalation exposure on cognitive functions in rats

Popis výsledku v původním jazyce

To study the influence of low level sarin exposure on cognitive functions, male albino Wistar rats were exposed to low concentrations of sarin for 60 minutes in the inhalation chamber. Three concentrations of sarin were chosen: clinically and laboratoryasymptomatic concentration (0.8 mg/L) - LEVEL 1 clinically aymptomatic concentration with significant inhibition of erythrocyte acetylcholinesterase (1.25 mg/L) - LEVEL 2 non-convulsive symptomatic concentration (2.5 mg/L) - LEVEL 3 In addition,one groupof rats was exposed to clinically asymptomatic concentration (1.25 mg/L) of sarin repeatedly (three times during one week). Testing of cognitive functions was carried out using the Y-maze evaluating learning and spatial memory. The avoidanc e behaviourof sarin-exposed rats in the Y-maze was tested several times within seven weeks following sarin inhalation exposure to look for any cognitive impairments. The results were compared to the Y-maze performance of control rats exposed to pure

Název v anglickém jazyce

The long term effects of low-level sarin inhalation exposure on cognitive functions in rats

Popis výsledku anglicky

To study the influence of low level sarin exposure on cognitive functions, male albino Wistar rats were exposed to low concentrations of sarin for 60 minutes in the inhalation chamber. Three concentrations of sarin were chosen: clinically and laboratoryasymptomatic concentration (0.8 mg/L) - LEVEL 1 clinically aymptomatic concentration with significant inhibition of erythrocyte acetylcholinesterase (1.25 mg/L) - LEVEL 2 non-convulsive symptomatic concentration (2.5 mg/L) - LEVEL 3 In addition,one groupof rats was exposed to clinically asymptomatic concentration (1.25 mg/L) of sarin repeatedly (three times during one week). Testing of cognitive functions was carried out using the Y-maze evaluating learning and spatial memory. The avoidanc e behaviourof sarin-exposed rats in the Y-maze was tested several times within seven weeks following sarin inhalation exposure to look for any cognitive impairments. The results were compared to the Y-maze performance of control rats exposed to pure

Druh

C - Kapitola v odborné knize

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Proceedings of Seventh International Symposium on protection against chemical and biological warfare agents

ISBN

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Počet stran výsledku

1

Strana od-do

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Počet stran knihy

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Název nakladatele

Commitee of Symposium

Místo vydání

Stockholm

Kód UT WoS kapitoly

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