Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG16__%2F03%3A00000900" target="_blank" >RIV/60162694:G16__/03:00000900 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G38__/03:00000900

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats

Popis výsledku v původním jazyce

To study the influence of pharmacological pretreatment (PANPAL) and antidotal treatment (obidoxime plus atropine) on tabun-induced neurotoxicity, male albino rats were poisoned with a lethal dose of tabun (280 mg/kg i.m.; 100% of LD50 value) and observedat 24 hours and 7 days following tabun challenge. The neurotoxicity of tabun was evaluated using a Functional observational battery and an automatic measurement of motor activity. Pharmacological pretreatment as well as antidotal treatment were a ble toeliminate most of tabun-induced neurotoxic effects observed at 24 hours following tabun poisoning. However, there was not significant difference between the efficacy of PANPAL and antidotal treatment to eliminate tabun-induced neurotoxicity in rats. Thecombination of PANPAL pretreatment and antidotal treatment seems to be slightly more effective in the elimination of tabun-induced neurotoxicity in rats at 24 hours following tabun challenge in comparison with the administration of PANPAL

Název v anglickém jazyce

Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats

Popis výsledku anglicky

To study the influence of pharmacological pretreatment (PANPAL) and antidotal treatment (obidoxime plus atropine) on tabun-induced neurotoxicity, male albino rats were poisoned with a lethal dose of tabun (280 mg/kg i.m.; 100% of LD50 value) and observedat 24 hours and 7 days following tabun challenge. The neurotoxicity of tabun was evaluated using a Functional observational battery and an automatic measurement of motor activity. Pharmacological pretreatment as well as antidotal treatment were a ble toeliminate most of tabun-induced neurotoxic effects observed at 24 hours following tabun poisoning. However, there was not significant difference between the efficacy of PANPAL and antidotal treatment to eliminate tabun-induced neurotoxicity in rats. Thecombination of PANPAL pretreatment and antidotal treatment seems to be slightly more effective in the elimination of tabun-induced neurotoxicity in rats at 24 hours following tabun challenge in comparison with the administration of PANPAL

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/OBVLAJEP20032" target="_blank" >OBVLAJEP20032: C-AGENS - Zdravotnická problematika ochrany živé síly proti aktuálním typům vojensky použitelných chemických látek</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicology

ISSN

0300-483X

e-ISSN

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Svazek periodika

185

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

11

Strana od-do

129-139

Kód UT WoS článku

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EID výsledku v databázi Scopus

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