Hodnocení kognitivního poškození tabunem u potkanů a jeho antidotní léčba

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG38__%2F04%3A00001179" target="_blank" >RIV/60162694:G38__/04:00001179 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The evaluation of tabun-induced cognitive impairment in rats and its antidotal treatment using the water maze test

Popis výsledku v původním jazyce

The mechanism of nerve agents (Tabun, Soman, Sarin, VX, etc.) toxicity consists in the irreversible inhibition of acetylcholinesterase (AChE, EC 3.1.1.7) resulting in excessive acetylcholine effects within the nervous system. The peripheral cholinergic system is well understood, while the central nervous system picture continues to evolve. Central cholinergic system is important for protective systems, locomotion, alertness and memory and in the regulation of a number of cyclic and periodic behaviors. Nerve agent-induced cholinergic effects are usually manifested immediately following high-level exposure, nevertheless, behavioural alterations and impairments of cognitive functions were found following acute exposure to nerve agents in the absence of any classic signs of cholinergic toxicity. Recently, researches are interested in such antidotes that not only allow live nerve agents-poisoned men, but also improve their life by the improvement of their central cognitive functions.

Název v anglickém jazyce

The evaluation of tabun-induced cognitive impairment in rats and its antidotal treatment using the water maze test

Popis výsledku anglicky

The mechanism of nerve agents (Tabun, Soman, Sarin, VX, etc.) toxicity consists in the irreversible inhibition of acetylcholinesterase (AChE, EC 3.1.1.7) resulting in excessive acetylcholine effects within the nervous system. The peripheral cholinergic system is well understood, while the central nervous system picture continues to evolve. Central cholinergic system is important for protective systems, locomotion, alertness and memory and in the regulation of a number of cyclic and periodic behaviors. Nerve agent-induced cholinergic effects are usually manifested immediately following high-level exposure, nevertheless, behavioural alterations and impairments of cognitive functions were found following acute exposure to nerve agents in the absence of any classic signs of cholinergic toxicity. Recently, researches are interested in such antidotes that not only allow live nerve agents-poisoned men, but also improve their life by the improvement of their central cognitive functions.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Homeostasis in Health and Disease

ISSN

0960-7560

e-ISSN

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Svazek periodika

43

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

3

Strana od-do

83-85

Kód UT WoS článku

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EID výsledku v databázi Scopus

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