Mini-review: A possible role for galanin in post-traumatic stress disorder

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG42__%2F21%3A00556977" target="_blank" >RIV/60162694:G42__/21:00556977 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S030439402100358X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S030439402100358X?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2021.135980" target="_blank" >10.1016/j.neulet.2021.135980</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mini-review: A possible role for galanin in post-traumatic stress disorder

Popis výsledku v původním jazyce

Several neuroendocrine systems have been implicated in post-traumatic stress disorder, including the meso-cortical and mesolimbic dopamine, the norepinephrine, the beta-endorphin, the serotonin, and the oxytocin systems. The interaction between these different systems remains, however, largely unknown and a generally accepted unifying theory is thus far lacking. In this review, we suggest that galanergic suppression of dopami-nergic neurons in the ventral tegmental may constitute the missing link in a post-traumatic feedback loop. In addition, we address the literature on the negative cross-antagonism in this brain region between the galanin 1 and mu-opioid receptors, which suggests that behavioural patterns which stimulate beta-endorphin, a natural mu-opioid receptors ligand, secretion may provide novel avenues for the treatment and prevention of PTSD, as well as for recruitment, training, and leadership processes in high-stress/high-risk professions such as the military, first responders and the police.

Název v anglickém jazyce

Mini-review: A possible role for galanin in post-traumatic stress disorder

Popis výsledku anglicky

Several neuroendocrine systems have been implicated in post-traumatic stress disorder, including the meso-cortical and mesolimbic dopamine, the norepinephrine, the beta-endorphin, the serotonin, and the oxytocin systems. The interaction between these different systems remains, however, largely unknown and a generally accepted unifying theory is thus far lacking. In this review, we suggest that galanergic suppression of dopami-nergic neurons in the ventral tegmental may constitute the missing link in a post-traumatic feedback loop. In addition, we address the literature on the negative cross-antagonism in this brain region between the galanin 1 and mu-opioid receptors, which suggests that behavioural patterns which stimulate beta-endorphin, a natural mu-opioid receptors ligand, secretion may provide novel avenues for the treatment and prevention of PTSD, as well as for recruitment, training, and leadership processes in high-stress/high-risk professions such as the military, first responders and the police.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

NEUROSCIENCE LETTERS

ISSN

0304-3940

e-ISSN

1872-7972

Svazek periodika

756

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

6

Strana od-do

135980

Kód UT WoS článku

000657100800002

EID výsledku v databázi Scopus

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