Srovnávání in vitro schopnosti současně užívaných oximů (pralidoximu, obidoximu, HI-6) v reaktivaci sarinem inhibované acetylcholinesterázy v rozličných částech prasečího mozku

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001311" target="_blank" >RIV/60162694:G44__/05:00001311 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A comparison of in vitro potency of currently available oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain

Popis výsledku v původním jazyce

A potency of currently used oximes to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain and the whole pig brain was evaluated using in vitro methods. Significant differences in reactivation potency among all tested oximes wereobserved. At concentration (10-4 M) corresponding to recommended doses in vivo, the oxime HI-6 seems to be more efficacious reactivator of sarin-inhibited AChE in the whole pig brain as well as in cerebral hemispheres and cerebellum compared to other oximes studied. Nevertheless, there are not any differences in the potency of oximes tested to reactivate sarin-inhibited AChE in medulla oblongata. Thus, the oxime HI-6 appears to be the most promising oxime among currently available oximes for the antidotal treatment of acute sarin poisonings although it is not more efficacious than other currently used oximes in medulla oblongata whose function is necessary for vital functions - respiration and circulation.

Název v anglickém jazyce

A comparison of in vitro potency of currently available oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain

Popis výsledku anglicky

A potency of currently used oximes to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain and the whole pig brain was evaluated using in vitro methods. Significant differences in reactivation potency among all tested oximes wereobserved. At concentration (10-4 M) corresponding to recommended doses in vivo, the oxime HI-6 seems to be more efficacious reactivator of sarin-inhibited AChE in the whole pig brain as well as in cerebral hemispheres and cerebellum compared to other oximes studied. Nevertheless, there are not any differences in the potency of oximes tested to reactivate sarin-inhibited AChE in medulla oblongata. Thus, the oxime HI-6 appears to be the most promising oxime among currently available oximes for the antidotal treatment of acute sarin poisonings although it is not more efficacious than other currently used oximes in medulla oblongata whose function is necessary for vital functions - respiration and circulation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/OBVLAJEP20032" target="_blank" >OBVLAJEP20032: C-AGENS - Zdravotnická problematika ochrany živé síly proti aktuálním typům vojensky použitelných chemických látek</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Toxicology

ISSN

0260-437X

e-ISSN

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Svazek periodika

25

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

271-276

Kód UT WoS článku

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EID výsledku v databázi Scopus

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