Substituované monokvarterní oximy jako reaktivátory cyklosarinem a chlorpyrifosem inhibované acetylcholinesterázy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F06%3A00001591" target="_blank" >RIV/60162694:G44__/06:00001591 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Substituted monoquaternary oximes as reactivators of cyclosarin and chlorpyrifos inhibited acetylcholinesterase

Popis výsledku v původním jazyce

This paper describes an in vitro study of three potential acetylcholinesterase AChE; EC 3.1.1.7) reactivatorsderived from a monoquaternary reactivator pralidoxime. Compounds used were pyridinium-2-aldoxime-4-carbamoyl-N-methyl iodide (TO231), pyridinium-2-aldoxime-4-ethoxycarbonyl-N-methyl iodide (TO237),and pyridinium-2-aldoxime-5-ethoxycarbonyl-N-methyl iodide (TO238). Pralidoxime and obidoxime wereused for comparison. Nerve agent cyclosarin and pesticide chlorpyrifos were used as organophosphoruscholinesterase inhibitors. The source of AChE was rat brain homogenate. None of the tested oximes was able to reactivate cyclosarin-inhibited AChE (at 1.0 mmol L-1 oxime concentration). In case of chlorpyrifos, TO231 was the most potent AChE reactivator withan 82 % reactivation at 1.0 mmol L-1 oxime concentration. Thisreactivating potency equals that of pralidoxime and obidoxime. TO238 was less effective, and TO237 did not reactivate chlorpyrifos-inhibited AChE at all. None of the tested AC

Název v anglickém jazyce

Substituted monoquaternary oximes as reactivators of cyclosarin and chlorpyrifos inhibited acetylcholinesterase

Popis výsledku anglicky

This paper describes an in vitro study of three potential acetylcholinesterase AChE; EC 3.1.1.7) reactivatorsderived from a monoquaternary reactivator pralidoxime. Compounds used were pyridinium-2-aldoxime-4-carbamoyl-N-methyl iodide (TO231), pyridinium-2-aldoxime-4-ethoxycarbonyl-N-methyl iodide (TO237),and pyridinium-2-aldoxime-5-ethoxycarbonyl-N-methyl iodide (TO238). Pralidoxime and obidoxime wereused for comparison. Nerve agent cyclosarin and pesticide chlorpyrifos were used as organophosphoruscholinesterase inhibitors. The source of AChE was rat brain homogenate. None of the tested oximes was able to reactivate cyclosarin-inhibited AChE (at 1.0 mmol L-1 oxime concentration). In case of chlorpyrifos, TO231 was the most potent AChE reactivator withan 82 % reactivation at 1.0 mmol L-1 oxime concentration. Thisreactivating potency equals that of pralidoxime and obidoxime. TO238 was less effective, and TO237 did not reactivate chlorpyrifos-inhibited AChE at all. None of the tested AC

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of Industrial Hygiene and Toxicology

ISSN

0004-1254

e-ISSN

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Svazek periodika

57

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

HR - Chorvatská republika

Počet stran výsledku

4

Strana od-do

387-390

Kód UT WoS článku

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EID výsledku v databázi Scopus

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