TLC kvarternich pyridiniových aldoximů, antidot organofosforových estrerázových inhibitorů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F07%3A00001808" target="_blank" >RIV/60162694:G44__/07:00001808 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

TLC of quaternary pyridinium aldoximes, antidotes of organophosphorus esterase inhibitors

Popis výsledku v původním jazyce

Quaternary pyridinium aldoximes have been analyzed by thin-layer chromatography. Their separation was adequate when silica plates were used with a mobile phase with a high water content. As a consequence of their limited migration, reversed-phase TLC wasnot appropriate for determination of the lipophilicity of quaternary pyridinium aldoximes. Displacement TLC of some quaternary pyridinium aldoximes is, nevertheless, possible using silica as stationary phase with water-acetone-hydrochloric acid mobile phases. Normal-phase TLC with different concentrations of organic modifier gave a series of R M values for the pyridinium aldoximes. Approximation of the different plots of R M against organic modifier concentration to straight lines afforded R M,0 valuesand the slopes of the lines. The R M,0 values and the slopes both serve as indicators of the hydrophilic character of the compounds.

Název v anglickém jazyce

TLC of quaternary pyridinium aldoximes, antidotes of organophosphorus esterase inhibitors

Popis výsledku anglicky

Quaternary pyridinium aldoximes have been analyzed by thin-layer chromatography. Their separation was adequate when silica plates were used with a mobile phase with a high water content. As a consequence of their limited migration, reversed-phase TLC wasnot appropriate for determination of the lipophilicity of quaternary pyridinium aldoximes. Displacement TLC of some quaternary pyridinium aldoximes is, nevertheless, possible using silica as stationary phase with water-acetone-hydrochloric acid mobile phases. Normal-phase TLC with different concentrations of organic modifier gave a series of R M values for the pyridinium aldoximes. Approximation of the different plots of R M against organic modifier concentration to straight lines afforded R M,0 valuesand the slopes of the lines. The R M,0 values and the slopes both serve as indicators of the hydrophilic character of the compounds.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JPC-Journal of Planar Chromatography-Modern TLC

ISSN

0933-4173

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

HU - Maďarsko

Počet stran výsledku

4

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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