Účinnost a dávkování antidot aplikovaných dafniím intoxikovaným nervově paralytickou látkou tabunem.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F08%3A00001928" target="_blank" >RIV/60162694:G44__/08:00001928 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/44555601:13440/08:00004247

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Efficacy and dosing of antidotes applied to Daphnia intoxicated by nerve agent tabun

Popis výsledku v původním jazyce

A new assay with Daphnia, which can be used as a time, cost, and human effort-saving tool in the development of effective antidotes against organophosphate intoxications, is presented. Five concentrations of atropine (antimuscarinic anticholinergics) aswell as a reactivator (trimedoxime) were tested to define the optimal dosage. Various reactivators (trimedoxime, obidoxime) were used to examine difference in effectivity of treatments. The most effective dose of trimedoxime corresponded to the 75% of its EC50(24) value, i.e. 77.85mgl-1. The most effective dose of atropine corresponded to the 25% of its EC50(24) value, i.e. 104.70mg l-1. The most effective treatment was a combined atropine-obidoxime treatment, followed by the combined atropine-trimedoxime treatment, the atropine only and the obidoxime only treatments. The efficacy of the trimedoxime only treatmentwas doubtful. The surprisingly high efficacy of obidoxime in the obidoxime only treatment indicates that some oximes might ac

Název v anglickém jazyce

Efficacy and dosing of antidotes applied to Daphnia intoxicated by nerve agent tabun

Popis výsledku anglicky

A new assay with Daphnia, which can be used as a time, cost, and human effort-saving tool in the development of effective antidotes against organophosphate intoxications, is presented. Five concentrations of atropine (antimuscarinic anticholinergics) aswell as a reactivator (trimedoxime) were tested to define the optimal dosage. Various reactivators (trimedoxime, obidoxime) were used to examine difference in effectivity of treatments. The most effective dose of trimedoxime corresponded to the 75% of its EC50(24) value, i.e. 77.85mgl-1. The most effective dose of atropine corresponded to the 25% of its EC50(24) value, i.e. 104.70mg l-1. The most effective treatment was a combined atropine-obidoxime treatment, followed by the combined atropine-trimedoxime treatment, the atropine only and the obidoxime only treatments. The efficacy of the trimedoxime only treatmentwas doubtful. The surprisingly high efficacy of obidoxime in the obidoxime only treatment indicates that some oximes might ac

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Toxicology and Pharmacology

ISSN

1382-6689

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

—

Kód UT WoS článku

000260521700004

EID výsledku v databázi Scopus

—