Novel bisquaternary oximes - reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F09%3A00002173" target="_blank" >RIV/60162694:G44__/09:00002173 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41330/09:30602 RIV/00216208:11160/09:00210143

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Novel bisquaternary oximes - reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon

Popis výsledku v původním jazyce

Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibited by paraoxon. Their reactivation activity was compared with standard reactivators-pralidoxime, obidoxime and HI-6-which are clinically used at present. As it resulted, none of the prepared compounds surpassed obidoxime, which is considered to be the most potent compound if used for reactivation of AChE inhibited by paraoxon. In case of BuChE reactivation, two compounds (K053 and K068) achieved similar results as obidoxime.

Název v anglickém jazyce

Novel bisquaternary oximes - reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon

Popis výsledku anglicky

Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibited by paraoxon. Their reactivation activity was compared with standard reactivators-pralidoxime, obidoxime and HI-6-which are clinically used at present. As it resulted, none of the prepared compounds surpassed obidoxime, which is considered to be the most potent compound if used for reactivation of AChE inhibited by paraoxon. In case of BuChE reactivation, two compounds (K053 and K068) achieved similar results as obidoxime.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/IAA603020901" target="_blank" >IAA603020901: Význam hub a aktinomycet pro rozklad odumřelé rostlinné hmoty v ekosystémech kontaminovaných těžkými kovy.</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecules

ISSN

1420-3049

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000273043200009

EID výsledku v databázi Scopus

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