The proteome of Francisella tularensis: methodology and mass spectral analysis for studying one of the most dangerous human pathogens

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The proteome of Francisella tularensis: methodology and mass spectral analysis for studying one of the most dangerous human pathogens

Popis výsledku v původním jazyce

Facultative Gram-negative intracellular bacterium Francisella tularensis (F. tularensis) is a causative agent of the zoonotic disease tularemia. This microbe is widely distributed only in the Northern hemisphere and there are five subspecies of F. tularensis: tularensis (also called F. tularensis type A), novicida, mediaasiatica, holarctica (F. tularensis, type B) and variant of holarctica found in Japan. Of them only F. tularensis subsp. tularensis and subsp. holarctica cause disease in humans. Subtypes holarctica and tularensis differ in their geographic distribution and also in their virulence for humans. Subtype tularensis that prevails in Northern America is considered the most virulent for humans. Minimal infectious dose is less than 10 CFU and amortality of 5 to 6 % in untreated cases of cutaneous disease. In contrast, subtype holarctica predominates in Europe and Asia, and it does not trigger fatal disease. Interest in F. tularensis substantially increased recently due to seri

Název v anglickém jazyce

The proteome of Francisella tularensis: methodology and mass spectral analysis for studying one of the most dangerous human pathogens

Popis výsledku anglicky

Facultative Gram-negative intracellular bacterium Francisella tularensis (F. tularensis) is a causative agent of the zoonotic disease tularemia. This microbe is widely distributed only in the Northern hemisphere and there are five subspecies of F. tularensis: tularensis (also called F. tularensis type A), novicida, mediaasiatica, holarctica (F. tularensis, type B) and variant of holarctica found in Japan. Of them only F. tularensis subsp. tularensis and subsp. holarctica cause disease in humans. Subtypes holarctica and tularensis differ in their geographic distribution and also in their virulence for humans. Subtype tularensis that prevails in Northern America is considered the most virulent for humans. Minimal infectious dose is less than 10 CFU and amortality of 5 to 6 % in untreated cases of cutaneous disease. In contrast, subtype holarctica predominates in Europe and Asia, and it does not trigger fatal disease. Interest in F. tularensis substantially increased recently due to seri

Druh

C - Kapitola v odborné knize

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Mass spectrometry for microbial proteomics

ISBN

978-0-470-68199-2

Počet stran výsledku

27

Strana od-do

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Počet stran knihy

509

Název nakladatele

Wiley (Chichester)

Místo vydání

Chichester

Kód UT WoS kapitoly

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