Role of ?-H2AX in DNA-damage response and its possible clinical applications
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002498" target="_blank" >RIV/60162694:G44__/11:00002498 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.vojenskaskola.cz/school/ud/fmhs/research_development/Documents/MMSL_2011_4_4_WWW.pdf" target="_blank" >http://www.vojenskaskola.cz/school/ud/fmhs/research_development/Documents/MMSL_2011_4_4_WWW.pdf</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Role of ?-H2AX in DNA-damage response and its possible clinical applications
Popis výsledku v původním jazyce
The integrity of the human genome is constantly threatened by exogenous or endogenous genotoxic agents that cause DNA damage. The ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are considered as the most deleterious forms of DNA damage which could lead to genomic instability and to cancer development, if left unrepaired. The DNA damage response (DDR) is comprised of a network of proteins that cooperate to regulate cell cycle progression and repair of DNA lesions. Our understanding of molecular basis of repair processes and of functions of repair proteins, as well as understanding of chromatin modifications may provide new possibilities in improvement of cancer management. Phosphorylation of histone variant H2AX at serine 139 (?-H2AX) and formation of ?-H2AX repair foci seems to be the most sensitive DNA damage marker in the chromatin flanking the free DNA double-stranded ends in DSBs. Monitoring of ?-H2AX levels can serve for early indication of cancer development, as
Název v anglickém jazyce
Role of ?-H2AX in DNA-damage response and its possible clinical applications
Popis výsledku anglicky
The integrity of the human genome is constantly threatened by exogenous or endogenous genotoxic agents that cause DNA damage. The ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are considered as the most deleterious forms of DNA damage which could lead to genomic instability and to cancer development, if left unrepaired. The DNA damage response (DDR) is comprised of a network of proteins that cooperate to regulate cell cycle progression and repair of DNA lesions. Our understanding of molecular basis of repair processes and of functions of repair proteins, as well as understanding of chromatin modifications may provide new possibilities in improvement of cancer management. Phosphorylation of histone variant H2AX at serine 139 (?-H2AX) and formation of ?-H2AX repair foci seems to be the most sensitive DNA damage marker in the chromatin flanking the free DNA double-stranded ends in DSBs. Monitoring of ?-H2AX levels can serve for early indication of cancer development, as
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Military Medical Science Letters
ISSN
0372-7025
e-ISSN
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Svazek periodika
80
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
9
Strana od-do
169-177
Kód UT WoS článku
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EID výsledku v databázi Scopus
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