Specific antibodies protect gamma-irradiated mice against Francisella tularensis infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43873094" target="_blank" >RIV/60162694:G44__/12:43873094 - isvavai.cz</a>

Výsledek na webu

<a href="http://ac.els-cdn.com/S0882401012001386/1-s2.0-S0882401012001386-main.pdf?_tid=8a6eae34-9780-11e2-b03e-00000aacb35e&acdnat=1364459090_410a27b7d29bef3f917b618f15380b4a" target="_blank" >http://ac.els-cdn.com/S0882401012001386/1-s2.0-S0882401012001386-main.pdf?_tid=8a6eae34-9780-11e2-b03e-00000aacb35e&acdnat=1364459090_410a27b7d29bef3f917b618f15380b4a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.micpath.2012.07.006" target="_blank" >10.1016/j.micpath.2012.07.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Specific antibodies protect gamma-irradiated mice against Francisella tularensis infection

Popis výsledku v původním jazyce

The role of antibodies in the course of Francisella tularensis infection is still a subject of debate. In this study, we demonstrate that passive transfer of immune sera protected irradiated mice against subsequent infection with attenuated as well as virulent strains of F. tularensis subsp. holarctica. Na?ve mice of BALB/c or C3H/CBi strains were subjected to passive transfer of sera obtained from immunized mice with live F. tularensis LVS, F. tularensis subsp. holarctica strain 15, heat-killed F. tularensis LVS, or heat killed strain 15 two hours before infection with lethal doses of LVS or strain 15. The passive transfer of sera obtained from immunized mice conferred full protection of na?ve unirradiated as well as sublethally irradiated mice against low lethal doses of infection with F. tularensis LVS or strain 15, in all variants of the experiments. Moreover, the passively protected mice that survived the primary infection with F. tularensis LVS were protected also against further

Název v anglickém jazyce

Specific antibodies protect gamma-irradiated mice against Francisella tularensis infection

Popis výsledku anglicky

The role of antibodies in the course of Francisella tularensis infection is still a subject of debate. In this study, we demonstrate that passive transfer of immune sera protected irradiated mice against subsequent infection with attenuated as well as virulent strains of F. tularensis subsp. holarctica. Na?ve mice of BALB/c or C3H/CBi strains were subjected to passive transfer of sera obtained from immunized mice with live F. tularensis LVS, F. tularensis subsp. holarctica strain 15, heat-killed F. tularensis LVS, or heat killed strain 15 two hours before infection with lethal doses of LVS or strain 15. The passive transfer of sera obtained from immunized mice conferred full protection of na?ve unirradiated as well as sublethally irradiated mice against low lethal doses of infection with F. tularensis LVS or strain 15, in all variants of the experiments. Moreover, the passively protected mice that survived the primary infection with F. tularensis LVS were protected also against further

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Microbial Pathogenesis

ISSN

0882-4010

e-ISSN

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Svazek periodika

53

Číslo periodika v rámci svazku

5-6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

259-268

Kód UT WoS článku

000310189300011

EID výsledku v databázi Scopus

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