Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle of Wistar rats
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874626" target="_blank" >RIV/60162694:G44__/12:43874626 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62156489:43210/12:43908626
Výsledek na webu
<a href="http://dx.doi.org/10.2478/s11532-012-0064-8" target="_blank" >http://dx.doi.org/10.2478/s11532-012-0064-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/s11532-012-0064-8" target="_blank" >10.2478/s11532-012-0064-8</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle of Wistar rats
Popis výsledku v původním jazyce
Selenium is a micronutrient, localized in the active sites of enzymes such as glutathione peroxidase and thioredoxin reductase, and participating together with these enzymes in an antioxidant defence system of organisms against free radicals. Administration of selenium is necessary for maintaining oxidative homeostasis. The present experiment is aimed at investigation of selenium impact on basal metabolic processes and selected antioxidants in a Wistar rat model, fed selenium in organic and inorganic forms. Liver, kidney, brain and muscle were sampled during a month-long feeding with four different doses of selenium (0.075 mg or 1.5 mg of inorganic and/or organic selenium per kg of feed). We found a significant reduction in glutathione level in liver tissue regardless of the form of the administered selenium. On the other hand, selenium caused a decreased glutathione reductase level in the liver and metallothionein level in the liver, kidney and muscle.
Název v anglickém jazyce
Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle of Wistar rats
Popis výsledku anglicky
Selenium is a micronutrient, localized in the active sites of enzymes such as glutathione peroxidase and thioredoxin reductase, and participating together with these enzymes in an antioxidant defence system of organisms against free radicals. Administration of selenium is necessary for maintaining oxidative homeostasis. The present experiment is aimed at investigation of selenium impact on basal metabolic processes and selected antioxidants in a Wistar rat model, fed selenium in organic and inorganic forms. Liver, kidney, brain and muscle were sampled during a month-long feeding with four different doses of selenium (0.075 mg or 1.5 mg of inorganic and/or organic selenium per kg of feed). We found a significant reduction in glutathione level in liver tissue regardless of the form of the administered selenium. On the other hand, selenium caused a decreased glutathione reductase level in the liver and metallothionein level in the liver, kidney and muscle.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CC - Organická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Central European Journal of Chemistry
ISSN
1895-1066
e-ISSN
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Svazek periodika
10
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
PL - Polská republika
Počet stran výsledku
10
Strana od-do
1442-1451
Kód UT WoS článku
000306695700005
EID výsledku v databázi Scopus
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