In vitro skin permeation and decontamination of the organophosphorus pesticide paraoxon under various physical conditions : evidence for a wash-in effect

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874671" target="_blank" >RIV/60162694:G44__/12:43874671 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3109/15376516.2012.686535" target="_blank" >http://dx.doi.org/10.3109/15376516.2012.686535</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/15376516.2012.686535" target="_blank" >10.3109/15376516.2012.686535</a>

Jazyk výsledku

čeština

Název v původním jazyce

In vitro skin permeation and decontamination of the organophosphorus pesticide paraoxon under various physical conditions : evidence for a wash-in effect

Popis výsledku v původním jazyce

Misuse of various chemicals, such as chemical warfare agents, industrial chemicals or pesticides during warfare or terrorists attacks requires adequate protection. Thus, development and evaluation of novel decontamination dispositives and techniques areneeded. In this study, in vitro permeation and decontamination of a potentially hazardous compound paraoxon, an active metabolite of organophosphorus pesticide parathion, was investigated. Skin permeation and decontamination experiments were carried outin modified Franz diffusion cells. Pig skin was used as a human skin model. Commercially produced detergent-based washing solutions FloraFreeTM and ArgosTM were used as decontamination means. The experiments were done under "warm", "cold", "dry" and "wet" skin conditions in order to determine an effect of various physical conditions on skin permeation of paraoxon and on a subsequent decontamination process. There was no significant difference in skin permeation of paraoxon under warm, co

Název v anglickém jazyce

In vitro skin permeation and decontamination of the organophosphorus pesticide paraoxon under various physical conditions : evidence for a wash-in effect

Popis výsledku anglicky

Misuse of various chemicals, such as chemical warfare agents, industrial chemicals or pesticides during warfare or terrorists attacks requires adequate protection. Thus, development and evaluation of novel decontamination dispositives and techniques areneeded. In this study, in vitro permeation and decontamination of a potentially hazardous compound paraoxon, an active metabolite of organophosphorus pesticide parathion, was investigated. Skin permeation and decontamination experiments were carried outin modified Franz diffusion cells. Pig skin was used as a human skin model. Commercially produced detergent-based washing solutions FloraFreeTM and ArgosTM were used as decontamination means. The experiments were done under "warm", "cold", "dry" and "wet" skin conditions in order to determine an effect of various physical conditions on skin permeation of paraoxon and on a subsequent decontamination process. There was no significant difference in skin permeation of paraoxon under warm, co

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/OVUOFVZ200803" target="_blank" >OVUOFVZ200803: SUBSTANCE - Vývoj nového činidla pro dekontaminaci a dezinfekci kůže na bázi micelárních substancí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicology Mechanisms and Methods

ISSN

1537-6516

e-ISSN

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Svazek periodika

22

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

520-525

Kód UT WoS článku

000307997700004

EID výsledku v databázi Scopus

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