Cholinergic antagonist 3-quinuclidinyl benzilate - Impact on learning and memory in Wistar rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F14%3A43875128" target="_blank" >RIV/60162694:G44__/14:43875128 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0166432814001430" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0166432814001430</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbr.2014.03.001" target="_blank" >10.1016/j.bbr.2014.03.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cholinergic antagonist 3-quinuclidinyl benzilate - Impact on learning and memory in Wistar rats

Popis výsledku v původním jazyce

3-Quinuclidinyl benzilate (QNB) represents a non-selective, competitive antagonist of cholinergic receptors, which has been previously used to generate cognitive deficits in animal models of neurodegenerative disorders. The aim of this study was evaluation of QNB potency for creation of cognitive impairment during the acquisition, consolidation and retrieval stages of learning and memory in rats. Male Wistar rats were subjected to a water maze task with hidden platform and a step-through passive avoidance task. The water maze test was carried out in two separate experiments focused on spatial learning (acquisition test) and long-term spatial memory (retrieval test). QNB doses (0.5, 1.0, 2.0 and 5.0 mg kg(-1)) were administered to rats intraperitoneallybefore training sessions (acquisition test) or before probe trial (retrieval test). A QNB dose of 2.0 mg kg(-1) was administered to rats in the passive avoidance task before training (acquisition test), immediately post-training (consoli

Název v anglickém jazyce

Cholinergic antagonist 3-quinuclidinyl benzilate - Impact on learning and memory in Wistar rats

Popis výsledku anglicky

3-Quinuclidinyl benzilate (QNB) represents a non-selective, competitive antagonist of cholinergic receptors, which has been previously used to generate cognitive deficits in animal models of neurodegenerative disorders. The aim of this study was evaluation of QNB potency for creation of cognitive impairment during the acquisition, consolidation and retrieval stages of learning and memory in rats. Male Wistar rats were subjected to a water maze task with hidden platform and a step-through passive avoidance task. The water maze test was carried out in two separate experiments focused on spatial learning (acquisition test) and long-term spatial memory (retrieval test). QNB doses (0.5, 1.0, 2.0 and 5.0 mg kg(-1)) were administered to rats intraperitoneallybefore training sessions (acquisition test) or before probe trial (retrieval test). A QNB dose of 2.0 mg kg(-1) was administered to rats in the passive avoidance task before training (acquisition test), immediately post-training (consoli

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/GAP303%2F12%2F0611" target="_blank" >GAP303/12/0611: Neurobehaviorální vyhodnocení účinnosti potenciálních léčiv Alzheimerovy choroby</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Behavioural Brain Research

ISSN

0166-4328

e-ISSN

—

Svazek periodika

266

Číslo periodika v rámci svazku

1 june

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

193-200

Kód UT WoS článku

000335805300025

EID výsledku v databázi Scopus

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