Seroepidemiology of whooping cough in the Czech Republic: estimates of incidence of infection in adults

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F17%3A43875757" target="_blank" >RIV/60162694:G44__/17:43875757 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/75010330:_____/17:00012509

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0033350617301920?via%3Dihub" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0033350617301920?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.puhe.2017.05.012" target="_blank" >10.1016/j.puhe.2017.05.012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Seroepidemiology of whooping cough in the Czech Republic: estimates of incidence of infection in adults

Popis výsledku v původním jazyce

Despite widespread vaccination programmes, pertussis remains a significant health burden in many countries. Low awareness of the disease, the high rate of asymptomatic cases in adults and difficulties with diagnosis could explain the under-reporting of pertussis. The lack of data on actual incidence constitutes an obstacle for public health authorities for the implementation of a vaccination strategy against pertussis in adults. The aim of this study was to evaluate the seroprevalence of antibodies against Bordetella pertussis infection in adults and to estimate the actual incidence of the disease compared with the reported incidence. The study was conducted in 2000 adult subjects aged &gt;= 18 years who had not received pertussis vaccination within the last 5 years. All subjects provided a blood sample for serum testing of IgG antibodies against pertussis toxin, performed by enzyme-linked immunosorbent assay, to indicate if they had an acute infection or if they had been infected with pertussis within the last 12 months or earlier. Results were validated in accordance with the guidelines of the European Sero-epidemiology Network 2 and were expressed in ESEN units/ml. A positive concentration of anti-pertussis toxin antibodies was demonstrated in 39.9% (n = 799) of all study subjects, and 0.40% (n = 8) of subjects had a concentration suggestive of a recent infection (within the last 12 months). The highest antibody seroprevalence was observed in subjects aged 18-29 years (1.46%). No cases of acute infection were detected. During the study period, the reported incidence of pertussis in the adult population was 0.84/100,000 inhabitants. Based on the seroprevalence results from this study, it is estimated that the actual incidence of pertussis could be as much as 699/100,000 inhabitants. The actual incidence of pertussis in adults in the CR could therefore be at least 200-fold higher than the reported incidence.

Název v anglickém jazyce

Seroepidemiology of whooping cough in the Czech Republic: estimates of incidence of infection in adults

Popis výsledku anglicky

Despite widespread vaccination programmes, pertussis remains a significant health burden in many countries. Low awareness of the disease, the high rate of asymptomatic cases in adults and difficulties with diagnosis could explain the under-reporting of pertussis. The lack of data on actual incidence constitutes an obstacle for public health authorities for the implementation of a vaccination strategy against pertussis in adults. The aim of this study was to evaluate the seroprevalence of antibodies against Bordetella pertussis infection in adults and to estimate the actual incidence of the disease compared with the reported incidence. The study was conducted in 2000 adult subjects aged &gt;= 18 years who had not received pertussis vaccination within the last 5 years. All subjects provided a blood sample for serum testing of IgG antibodies against pertussis toxin, performed by enzyme-linked immunosorbent assay, to indicate if they had an acute infection or if they had been infected with pertussis within the last 12 months or earlier. Results were validated in accordance with the guidelines of the European Sero-epidemiology Network 2 and were expressed in ESEN units/ml. A positive concentration of anti-pertussis toxin antibodies was demonstrated in 39.9% (n = 799) of all study subjects, and 0.40% (n = 8) of subjects had a concentration suggestive of a recent infection (within the last 12 months). The highest antibody seroprevalence was observed in subjects aged 18-29 years (1.46%). No cases of acute infection were detected. During the study period, the reported incidence of pertussis in the adult population was 0.84/100,000 inhabitants. Based on the seroprevalence results from this study, it is estimated that the actual incidence of pertussis could be as much as 699/100,000 inhabitants. The actual incidence of pertussis in adults in the CR could therefore be at least 200-fold higher than the reported incidence.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30302 - Epidemiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Public Health

ISSN

0033-3506

e-ISSN

—

Svazek periodika

2017

Číslo periodika v rámci svazku

150

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

77-83

Kód UT WoS článku

000411305900011

EID výsledku v databázi Scopus

2-s2.0-85031721578