Therapeutical strategies for anxiety and anxiety-like disorders using plant-derived natural compounds and plante extracts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F17%3A43889335" target="_blank" >RIV/60162694:G44__/17:43889335 - isvavai.cz</a>

Výsledek na webu

<a href="https://ac.els-cdn.com/S0753332217326380/1-s2.0-S0753332217326380-main.pdf?_tid=1e02d978-ebae-11e7-ba98-00000aab0f6b&acdnat=1514452052_2b827b433b614eaec48b3b7b2fca5a67" target="_blank" >https://ac.els-cdn.com/S0753332217326380/1-s2.0-S0753332217326380-main.pdf?_tid=1e02d978-ebae-11e7-ba98-00000aab0f6b&acdnat=1514452052_2b827b433b614eaec48b3b7b2fca5a67</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biopha.2017.08.107" target="_blank" >10.1016/j.biopha.2017.08.107</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Therapeutical strategies for anxiety and anxiety-like disorders using plant-derived natural compounds and plante extracts

Popis výsledku v původním jazyce

Anxiety and anxiety-like disorders describe many mental disorders, yet fear is a common overwhelming symptom often leading to depression. Currently two basic strategies are discussed to treat anxiety: pharmacotherapy or psychotherapy. In the pharmacotherapeutical clinical approach, several conventional synthetic anxiolytic drugs are being used with several adverse effects. Therefore, studies to find suitable safe medicines from natural sources are being sought by researchers. The results of a plethora experimental studies demonstrated that dietary phytochemicals like alkaloids, terpenes, flavonoids, phenolic acids, lignans, cinnamates, and saponins or various plant extracts with the mixture of different phytochemicals possess anxiolytic effects in a wide range of animal models of anxiety. The involved mechanisms of anxiolytics action include interaction with γ-aminobutyric acid A receptors at benzodiazepine (BZD) and non-BZD sites with various affinity to different subunits, serotonergic 5-hydrodytryptamine receptors, noradrenergic and dopaminergic systems, glutamate receptors, and cannabinoid receptors. This review focuses on the use of both plant-derived natural compounds and plant extracts with anxiolytic effects, describing their biological effects and clinical application.

Název v anglickém jazyce

Therapeutical strategies for anxiety and anxiety-like disorders using plant-derived natural compounds and plante extracts

Popis výsledku anglicky

Anxiety and anxiety-like disorders describe many mental disorders, yet fear is a common overwhelming symptom often leading to depression. Currently two basic strategies are discussed to treat anxiety: pharmacotherapy or psychotherapy. In the pharmacotherapeutical clinical approach, several conventional synthetic anxiolytic drugs are being used with several adverse effects. Therefore, studies to find suitable safe medicines from natural sources are being sought by researchers. The results of a plethora experimental studies demonstrated that dietary phytochemicals like alkaloids, terpenes, flavonoids, phenolic acids, lignans, cinnamates, and saponins or various plant extracts with the mixture of different phytochemicals possess anxiolytic effects in a wide range of animal models of anxiety. The involved mechanisms of anxiolytics action include interaction with γ-aminobutyric acid A receptors at benzodiazepine (BZD) and non-BZD sites with various affinity to different subunits, serotonergic 5-hydrodytryptamine receptors, noradrenergic and dopaminergic systems, glutamate receptors, and cannabinoid receptors. This review focuses on the use of both plant-derived natural compounds and plant extracts with anxiolytic effects, describing their biological effects and clinical application.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedicine and Pharmacotherapy

ISSN

0753-3322

e-ISSN

—

Svazek periodika

95

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

10

Strana od-do

437-446

Kód UT WoS článku

000417744400052

EID výsledku v databázi Scopus

2-s2.0-85028373064