Vše

Co hledáte?

Vše
Projekty
Výsledky výzkumu
Subjekty

Rychlé hledání

  • Projekty podpořené TA ČR
  • Významné projekty
  • Projekty s nejvyšší státní podporou
  • Aktuálně běžící projekty

Chytré vyhledávání

  • Takto najdu konkrétní +slovo
  • Takto z výsledků -slovo zcela vynechám
  • “Takto můžu najít celou frázi”

Serological survey of mumps antibodies in adults in the Czech Republic and the need for changes to the vaccination strategy

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F18%3A43889490" target="_blank" >RIV/60162694:G44__/18:43889490 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00179906:_____/18:10382147

  • Výsledek na webu

    <a href="https://www.tandfonline.com/doi/abs/10.1080/21645515.2017.1412021?journalCode=khvi20" target="_blank" >https://www.tandfonline.com/doi/abs/10.1080/21645515.2017.1412021?journalCode=khvi20</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1080/21645515.2017.1412021" target="_blank" >10.1080/21645515.2017.1412021</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Serological survey of mumps antibodies in adults in the Czech Republic and the need for changes to the vaccination strategy

  • Popis výsledku v původním jazyce

    Mumps outbreaks, especially in adolescents and young adults, have been reported in the Czech Republic. The aim of the presented study was to determine the seroprevalence of specific IgG antibodies against mumps in the adult population of the Czech Republic. The study was designed as a multicenter serological survey of adults aged 18years and over. Specific IgG antibodies against mumps were detected in blood samples using an enzyme-linked immunosorbent assay (ELISA). A total of 1,911 serum samples were examined. The overall seropositivity reached 55.3%. In individual age groups, the highest seropositivity 63% (63.5-65.2%) was recorded in adults aged 40years and over; the lowest seropositivity was found in adults aged 18-29years (27.4%). The difference in seropositivity rate between the 18-29years age group and the 40years and over age groups was statistically significant (p &lt; 0.001). Only the 18-29years age group included both vaccinated and unvaccinated (born in the pre-vaccine era) individuals. In vaccinated individuals, seropositivity was reported in only 19.1% of persons; in unvaccinated individuals, seropositivity reached 48.2%. Our results demonstrate the long-term persistence of antibodies following natural infection and the decrease in seropositivity that occurs after vaccination over time. This immunity waning may account for the higher susceptibility of adolescents and young adults to mumps. Therefore, the current vaccination program in the Czech Republic could be considered as less effective. It will be modified with the shifting of the second dose of vaccine from two years of age to the preschool age.

  • Název v anglickém jazyce

    Serological survey of mumps antibodies in adults in the Czech Republic and the need for changes to the vaccination strategy

  • Popis výsledku anglicky

    Mumps outbreaks, especially in adolescents and young adults, have been reported in the Czech Republic. The aim of the presented study was to determine the seroprevalence of specific IgG antibodies against mumps in the adult population of the Czech Republic. The study was designed as a multicenter serological survey of adults aged 18years and over. Specific IgG antibodies against mumps were detected in blood samples using an enzyme-linked immunosorbent assay (ELISA). A total of 1,911 serum samples were examined. The overall seropositivity reached 55.3%. In individual age groups, the highest seropositivity 63% (63.5-65.2%) was recorded in adults aged 40years and over; the lowest seropositivity was found in adults aged 18-29years (27.4%). The difference in seropositivity rate between the 18-29years age group and the 40years and over age groups was statistically significant (p &lt; 0.001). Only the 18-29years age group included both vaccinated and unvaccinated (born in the pre-vaccine era) individuals. In vaccinated individuals, seropositivity was reported in only 19.1% of persons; in unvaccinated individuals, seropositivity reached 48.2%. Our results demonstrate the long-term persistence of antibodies following natural infection and the decrease in seropositivity that occurs after vaccination over time. This immunity waning may account for the higher susceptibility of adolescents and young adults to mumps. Therefore, the current vaccination program in the Czech Republic could be considered as less effective. It will be modified with the shifting of the second dose of vaccine from two years of age to the preschool age.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30102 - Immunology

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2018

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Human Vaccines and Immunotherapeutics

  • ISSN

    2164-5515

  • e-ISSN

  • Svazek periodika

    14

  • Číslo periodika v rámci svazku

    4

  • Stát vydavatele periodika

    US - Spojené státy americké

  • Počet stran výsledku

    7

  • Strana od-do

    887-893

  • Kód UT WoS článku

    000429600000023

  • EID výsledku v databázi Scopus

    2-s2.0-85040961492