Serological survey of mumps antibodies in adults in the Czech Republic and the need for changes to the vaccination strategy
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F18%3A43889490" target="_blank" >RIV/60162694:G44__/18:43889490 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00179906:_____/18:10382147
Výsledek na webu
<a href="https://www.tandfonline.com/doi/abs/10.1080/21645515.2017.1412021?journalCode=khvi20" target="_blank" >https://www.tandfonline.com/doi/abs/10.1080/21645515.2017.1412021?journalCode=khvi20</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/21645515.2017.1412021" target="_blank" >10.1080/21645515.2017.1412021</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Serological survey of mumps antibodies in adults in the Czech Republic and the need for changes to the vaccination strategy
Popis výsledku v původním jazyce
Mumps outbreaks, especially in adolescents and young adults, have been reported in the Czech Republic. The aim of the presented study was to determine the seroprevalence of specific IgG antibodies against mumps in the adult population of the Czech Republic. The study was designed as a multicenter serological survey of adults aged 18years and over. Specific IgG antibodies against mumps were detected in blood samples using an enzyme-linked immunosorbent assay (ELISA). A total of 1,911 serum samples were examined. The overall seropositivity reached 55.3%. In individual age groups, the highest seropositivity 63% (63.5-65.2%) was recorded in adults aged 40years and over; the lowest seropositivity was found in adults aged 18-29years (27.4%). The difference in seropositivity rate between the 18-29years age group and the 40years and over age groups was statistically significant (p < 0.001). Only the 18-29years age group included both vaccinated and unvaccinated (born in the pre-vaccine era) individuals. In vaccinated individuals, seropositivity was reported in only 19.1% of persons; in unvaccinated individuals, seropositivity reached 48.2%. Our results demonstrate the long-term persistence of antibodies following natural infection and the decrease in seropositivity that occurs after vaccination over time. This immunity waning may account for the higher susceptibility of adolescents and young adults to mumps. Therefore, the current vaccination program in the Czech Republic could be considered as less effective. It will be modified with the shifting of the second dose of vaccine from two years of age to the preschool age.
Název v anglickém jazyce
Serological survey of mumps antibodies in adults in the Czech Republic and the need for changes to the vaccination strategy
Popis výsledku anglicky
Mumps outbreaks, especially in adolescents and young adults, have been reported in the Czech Republic. The aim of the presented study was to determine the seroprevalence of specific IgG antibodies against mumps in the adult population of the Czech Republic. The study was designed as a multicenter serological survey of adults aged 18years and over. Specific IgG antibodies against mumps were detected in blood samples using an enzyme-linked immunosorbent assay (ELISA). A total of 1,911 serum samples were examined. The overall seropositivity reached 55.3%. In individual age groups, the highest seropositivity 63% (63.5-65.2%) was recorded in adults aged 40years and over; the lowest seropositivity was found in adults aged 18-29years (27.4%). The difference in seropositivity rate between the 18-29years age group and the 40years and over age groups was statistically significant (p < 0.001). Only the 18-29years age group included both vaccinated and unvaccinated (born in the pre-vaccine era) individuals. In vaccinated individuals, seropositivity was reported in only 19.1% of persons; in unvaccinated individuals, seropositivity reached 48.2%. Our results demonstrate the long-term persistence of antibodies following natural infection and the decrease in seropositivity that occurs after vaccination over time. This immunity waning may account for the higher susceptibility of adolescents and young adults to mumps. Therefore, the current vaccination program in the Czech Republic could be considered as less effective. It will be modified with the shifting of the second dose of vaccine from two years of age to the preschool age.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30102 - Immunology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Human Vaccines and Immunotherapeutics
ISSN
2164-5515
e-ISSN
—
Svazek periodika
14
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
887-893
Kód UT WoS článku
000429600000023
EID výsledku v databázi Scopus
2-s2.0-85040961492