Antidotes Against Methanol Poisoning: A Review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00541690" target="_blank" >RIV/60162694:G44__/19:00541690 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.eurekaselect.com/170658/article" target="_blank" >http://www.eurekaselect.com/170658/article</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1389557519666190312150407" target="_blank" >10.2174/1389557519666190312150407</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antidotes Against Methanol Poisoning: A Review

Popis výsledku v původním jazyce

Methanol is the simplest alcohol. Compared to ethanol that is fully detoxified by metabolism. Methanol gets activated in toxic products by the enzymes, alcohol dehydrogenase and aldehyde dehydrogenase. Paradoxically, the same enzymes convert ethanol to harmless acetic acid. This review is focused on a discussion and overview of the literature devoted to methanol toxicology and antidotal therapy. Regarding the antidotal therapy, three main approaches are presented in the text: 1) ethanol as a competitive inhibitor in alcohol dehydrogenase; 2) use of drugs like fomepizole inhibiting alcohol dehydrogenase; 3) tetrahydrofolic acid and its analogues reacting with the formate as a final product of methanol metabolism. All the types of antidotal therapies are described and bow they protect from toxic sequelae of methanol is explained.

Název v anglickém jazyce

Antidotes Against Methanol Poisoning: A Review

Popis výsledku anglicky

Methanol is the simplest alcohol. Compared to ethanol that is fully detoxified by metabolism. Methanol gets activated in toxic products by the enzymes, alcohol dehydrogenase and aldehyde dehydrogenase. Paradoxically, the same enzymes convert ethanol to harmless acetic acid. This review is focused on a discussion and overview of the literature devoted to methanol toxicology and antidotal therapy. Regarding the antidotal therapy, three main approaches are presented in the text: 1) ethanol as a competitive inhibitor in alcohol dehydrogenase; 2) use of drugs like fomepizole inhibiting alcohol dehydrogenase; 3) tetrahydrofolic acid and its analogues reacting with the formate as a final product of methanol metabolism. All the types of antidotal therapies are described and bow they protect from toxic sequelae of methanol is explained.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

<a href="/cs/project/TH03030336" target="_blank" >TH03030336: Kolorimetrický senzor pro diagnostiku otrav pesticidy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mini-Reviews in Medicinal Chemistry

ISSN

1389-5575

e-ISSN

1875-5607

Svazek periodika

19

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

8

Strana od-do

1126-1133

Kód UT WoS článku

000482187700002

EID výsledku v databázi Scopus

2-s2.0-85071771498