Development of a method for the derivatization of ethanolamines and its application to sand samples

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG45__%2F23%3A00557038" target="_blank" >RIV/60162694:G45__/23:00557038 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.shd-pub.org.rs/index.php/JSCS/article/view/10507" target="_blank" >https://www.shd-pub.org.rs/index.php/JSCS/article/view/10507</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2298/JSC210312047R" target="_blank" >10.2298/JSC210312047R</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Development of a method for the derivatization of ethanolamines and its application to sand samples

Popis výsledku v původním jazyce

Nitrogen mustards are dangerous and available blistering chemical warfare agents. In the presented study, six derivatization methods are compared for the analysis of degradation products of the most important blistering nitrogen mustards (ethyl diethanolamine, methyl diethanolamine and triethanolamine) by gas chromatography coupled with mass spectrometry. Five silylation methods (using BSTFA and BSA) and one trifluoroacetylation method (using TFAA) were tested. The derivatization reactions were performed in acetonitrile. As the method with optimal results, trifluoroacetylation by TFAA was selected. Analytes reacted with the corresponding reagent rapidly, quantitatively, with stable kinetics and at room temperature. Calibration curves for quantitative analysis of ethanolamines after TFAA derivatization were created. The corresponding detection limits varied between 9x10(-3) and 7x10(-5) mmol.dm(-3) for the tested analytes. The developed method was applied for the analysis of ethanolamines after extraction from sand using acetonitrile. Limits of detection were 11.4 to 12.3 mu g of the analyte in 1 g of sand. The use of the developed method in military deployable laboratories designated for the rapid identification of chemical warfare agents and corresponding degradation products is encouraged.

Název v anglickém jazyce

Development of a method for the derivatization of ethanolamines and its application to sand samples

Popis výsledku anglicky

Nitrogen mustards are dangerous and available blistering chemical warfare agents. In the presented study, six derivatization methods are compared for the analysis of degradation products of the most important blistering nitrogen mustards (ethyl diethanolamine, methyl diethanolamine and triethanolamine) by gas chromatography coupled with mass spectrometry. Five silylation methods (using BSTFA and BSA) and one trifluoroacetylation method (using TFAA) were tested. The derivatization reactions were performed in acetonitrile. As the method with optimal results, trifluoroacetylation by TFAA was selected. Analytes reacted with the corresponding reagent rapidly, quantitatively, with stable kinetics and at room temperature. Calibration curves for quantitative analysis of ethanolamines after TFAA derivatization were created. The corresponding detection limits varied between 9x10(-3) and 7x10(-5) mmol.dm(-3) for the tested analytes. The developed method was applied for the analysis of ethanolamines after extraction from sand using acetonitrile. Limits of detection were 11.4 to 12.3 mu g of the analyte in 1 g of sand. The use of the developed method in military deployable laboratories designated for the rapid identification of chemical warfare agents and corresponding degradation products is encouraged.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10400 - Chemical sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY

ISSN

0352-5139

e-ISSN

1820-7421

Svazek periodika

87

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

RS - Srbská republika

Počet stran výsledku

13

Strana od-do

233-245

Kód UT WoS článku

000719807500001

EID výsledku v databázi Scopus

2-s2.0-85126696839