Inhibitory effect of hop fractions against gram-positive multi-resistant bacteria. A pilot study.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60193697%3A_____%2F18%3AN0000036" target="_blank" >RIV/60193697:_____/18:N0000036 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/18:43889942 RIV/61989592:15110/18:73593424

Výsledek na webu

<a href="http://biomed.papers.upol.cz/artkey/bio-201804-0005_inhibitory_effect_of_hop_fractions_against_gram-positive_multi-resistant_bacteria_a_pilot_study.php" target="_blank" >http://biomed.papers.upol.cz/artkey/bio-201804-0005_inhibitory_effect_of_hop_fractions_against_gram-positive_multi-resistant_bacteria_a_pilot_study.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2018.026" target="_blank" >10.5507/bp.2018.026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Inhibitory effect of hop fractions against gram-positive multi-resistant bacteria. A pilot study.

Popis výsledku v původním jazyce

Aim: Our research focused on the antimicrobial effects of purified hop (Humulus lupulus L.) fractions including α-bitter acids (humulones), β-bitter acids (lupulones) and xanthohumol, and a commercial CO2 hop extract of bitter acids against reference and multi-resistant strains of Gram-positive and Gram-negative bacteria and against selected yeast strains. Methods: In vitro testing of antimicrobial activity was performed according to standard testing protocols (EUCAST). The effects of hop extracts on bacterial/yeast strains at concentrations below MICs were also determined and the antimicrobial potential of hop extracts was compared with selected antibiotics using optical density measurement. Results: The fractions were effective not only against reference strains of Gram-positive bacteria but, more importantly, against their methicillin- and vancomycin-resistant variants. No antimicrobial effect was detected against Gram-negative bacterial strains. Among the tested substances, xanthohumol was identified as the hop fraction with the most potent antimicrobial properties. It was also found that hop substances exerted their antimicrobial effects at concentrations considerably lower than the determined MICs, with the strongest effect in case of α-bitter acids in enterococci. Conclusion: The search for and research of new compounds with antimicrobial properties represents a possible solution to the current global problem of bacterial resistance. Our data suggest a desirable activity of hop fractions against some multi-resistant bacterial strains. Thus, hops might find use as a source of potential antimicrobial agents applicable in both human and veterinary medicine.

Název v anglickém jazyce

Inhibitory effect of hop fractions against gram-positive multi-resistant bacteria. A pilot study.

Popis výsledku anglicky

Aim: Our research focused on the antimicrobial effects of purified hop (Humulus lupulus L.) fractions including α-bitter acids (humulones), β-bitter acids (lupulones) and xanthohumol, and a commercial CO2 hop extract of bitter acids against reference and multi-resistant strains of Gram-positive and Gram-negative bacteria and against selected yeast strains. Methods: In vitro testing of antimicrobial activity was performed according to standard testing protocols (EUCAST). The effects of hop extracts on bacterial/yeast strains at concentrations below MICs were also determined and the antimicrobial potential of hop extracts was compared with selected antibiotics using optical density measurement. Results: The fractions were effective not only against reference strains of Gram-positive bacteria but, more importantly, against their methicillin- and vancomycin-resistant variants. No antimicrobial effect was detected against Gram-negative bacterial strains. Among the tested substances, xanthohumol was identified as the hop fraction with the most potent antimicrobial properties. It was also found that hop substances exerted their antimicrobial effects at concentrations considerably lower than the determined MICs, with the strongest effect in case of α-bitter acids in enterococci. Conclusion: The search for and research of new compounds with antimicrobial properties represents a possible solution to the current global problem of bacterial resistance. Our data suggest a desirable activity of hop fractions against some multi-resistant bacterial strains. Thus, hops might find use as a source of potential antimicrobial agents applicable in both human and veterinary medicine.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/GA14-10233S" target="_blank" >GA14-10233S: Humulus Lupulus L. - zdroj látek s antimikrobiálními účinky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

1804-7521

Svazek periodika

162

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

276-283

Kód UT WoS článku

000457488200005

EID výsledku v databázi Scopus

2-s2.0-85057316219