Dědičnost maligního melanomu u populace MeLim miniaturních prasat

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F04%3A7286" target="_blank" >RIV/60460709:41210/04:7286 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/04:00108505

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Inheritance of malignant melanoma in the MeLiM strain of miniature pigs

Popis výsledku v původním jazyce

Selective breeding of miniature pigs bearing cutaneus tumours resulted in the establishment of the MeLiM strain with malignant melanoma.The inheritance of melanoma was tested in a two-generation kindred comprising 456 progeny from 78 litters. Melanomas were recognisable visually as black-pigmented melanoma forms known in human melanoma, i.e. pigmented naevi, dysplastic naevi, superficial spreading melanoma and nodular malignant melanoma, were found in the MeLiM pigs. Because the occurence of nodular malignant melanoma segregated in all recorded litters we have included only this form in the genetic analysis. The tumours were nodular with exophytic growth over the skin surface. All showed similar histopathological features, vertical growh to muscle fascia and high metastatic activity. We hypothesize, on the basis of segregation ratios obtained from various mating types, that the mode of inheritance of nodular melanoma in the MeLim strain is probably controlled by three genes.

Název v anglickém jazyce

Inheritance of malignant melanoma in the MeLiM strain of miniature pigs

Popis výsledku anglicky

Selective breeding of miniature pigs bearing cutaneus tumours resulted in the establishment of the MeLiM strain with malignant melanoma.The inheritance of melanoma was tested in a two-generation kindred comprising 456 progeny from 78 litters. Melanomas were recognisable visually as black-pigmented melanoma forms known in human melanoma, i.e. pigmented naevi, dysplastic naevi, superficial spreading melanoma and nodular malignant melanoma, were found in the MeLiM pigs. Because the occurence of nodular malignant melanoma segregated in all recorded litters we have included only this form in the genetic analysis. The tumours were nodular with exophytic growth over the skin surface. All showed similar histopathological features, vertical growh to muscle fascia and high metastatic activity. We hypothesize, on the basis of segregation ratios obtained from various mating types, that the mode of inheritance of nodular melanoma in the MeLim strain is probably controlled by three genes.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinary Medicine - Czech

ISSN

0375-8427

e-ISSN

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Svazek periodika

49

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

453-459

Kód UT WoS článku

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EID výsledku v databázi Scopus

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