Bisphenol S affects quality of mouse oocytes after in vivo treatment
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F16%3AN0000011" target="_blank" >RIV/60460709:41210/16:N0000011 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Bisphenol S affects quality of mouse oocytes after in vivo treatment
Popis výsledku v původním jazyce
Endocrine disruptors, such as fytoestrogens or bisphenols, represent a serious threat for human reproduction because already extremely low doses show biological effect. The negative effect of bisphenol A has been described and female reproduction failures, including abortion of oocyte maturation, oxidative stress incidence and disruption of spindle formation, as well as inadequate chromatin changes, were observed. Bisphenol S (BPS) has recently become ordinarily used in plastic and other materials to replace bisphenol A, altough its biological effect remains unknown. Based on similar chemical structures of both molecules, we hypothesized that also BPS causes disruption of meiotic spindle formation and chromatin damage.
Název v anglickém jazyce
Bisphenol S affects quality of mouse oocytes after in vivo treatment
Popis výsledku anglicky
Endocrine disruptors, such as fytoestrogens or bisphenols, represent a serious threat for human reproduction because already extremely low doses show biological effect. The negative effect of bisphenol A has been described and female reproduction failures, including abortion of oocyte maturation, oxidative stress incidence and disruption of spindle formation, as well as inadequate chromatin changes, were observed. Bisphenol S (BPS) has recently become ordinarily used in plastic and other materials to replace bisphenol A, altough its biological effect remains unknown. Based on similar chemical structures of both molecules, we hypothesized that also BPS causes disruption of meiotic spindle formation and chromatin damage.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
FK - Gynekologie a porodnictví
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/QJ1510138" target="_blank" >QJ1510138: Inovace biotechnologií v reprodukci hospodářských zvířat</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů