Bisphenol S negatively affects the meiotic maturation of pig oocytes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F17%3A73469" target="_blank" >RIV/60460709:41210/17:73469 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1038/s41598-017-00570-5" target="_blank" >http://dx.doi.org/10.1038/s41598-017-00570-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-017-00570-5" target="_blank" >10.1038/s41598-017-00570-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bisphenol S negatively affects the meiotic maturation of pig oocytes

Popis výsledku v původním jazyce

Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However, the effects of BPS are not well characterized, and its specific effects on reproduction and fertility remain unknown. It is therefore necessary to evaluate any effects of BPS on mammalian oocytes. The present study is the first to demonstrate the markedly negative effects of BPS on pig oocyte maturation in vitro, even at doses lower than those humans are exposed to in the environment. Our results demonstrate (1) an effect of BPS on the course of the meiotic cell cycle, (2) the failure of tubulin fibre formation, which controls proper chromosome movement, (3) changes in the supply of maternal mRNA, (4) changes in the protein amounts and distribution of oestrogen receptors alpha and beta and of aromatase, a

Název v anglickém jazyce

Bisphenol S negatively affects the meiotic maturation of pig oocytes

Popis výsledku anglicky

Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However, the effects of BPS are not well characterized, and its specific effects on reproduction and fertility remain unknown. It is therefore necessary to evaluate any effects of BPS on mammalian oocytes. The present study is the first to demonstrate the markedly negative effects of BPS on pig oocyte maturation in vitro, even at doses lower than those humans are exposed to in the environment. Our results demonstrate (1) an effect of BPS on the course of the meiotic cell cycle, (2) the failure of tubulin fibre formation, which controls proper chromosome movement, (3) changes in the supply of maternal mRNA, (4) changes in the protein amounts and distribution of oestrogen receptors alpha and beta and of aromatase, a

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/QJ1510138" target="_blank" >QJ1510138: Inovace biotechnologií v reprodukci hospodářských zvířat</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

N

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

1-11

Kód UT WoS článku

000397528600017

EID výsledku v databázi Scopus

2-s2.0-85016836270