Effects of Zearalenone, alpha Zearalenol, and Genistein on Boar Sperm Motility In Vitro

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F17%3A74031" target="_blank" >RIV/60460709:41210/17:74031 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.17221/19/2017-CJAS" target="_blank" >http://dx.doi.org/10.17221/19/2017-CJAS</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17221/19/2017-CJAS" target="_blank" >10.17221/19/2017-CJAS</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of Zearalenone, alpha Zearalenol, and Genistein on Boar Sperm Motility In Vitro

Popis výsledku v původním jazyce

Genistein (GEN) and zearalenone (ZEA), environmental oestrogens commonly present in feedstuff for pigs, are known for their effects on reproductive functions. The aim was to verify the in vitro effects of 0,5 to 20 microM concentrations of GEN, ZEA and its metabolite alpha zearalenol (aZOL) on pig sperm motility. A dose dependent increase of the immotile sperm amount against fast and medium fast sperm clusters was observed with all three oestrogens from the lowest concentrations tested. Individual CASA (computer assisted sperm analysis) parameters of motile sperms seemed to be less sensitive indicators. This should be considered especially in toxicological research on a sperm model. Background of inconsistencies in to date published papers is discussed. The results shift the effective concentrations of ZEA, aZOL, and GEN to values achievable in vivo and raises the questions of risk assessment of these compounds in pig reproduction.

Název v anglickém jazyce

Effects of Zearalenone, alpha Zearalenol, and Genistein on Boar Sperm Motility In Vitro

Popis výsledku anglicky

Genistein (GEN) and zearalenone (ZEA), environmental oestrogens commonly present in feedstuff for pigs, are known for their effects on reproductive functions. The aim was to verify the in vitro effects of 0,5 to 20 microM concentrations of GEN, ZEA and its metabolite alpha zearalenol (aZOL) on pig sperm motility. A dose dependent increase of the immotile sperm amount against fast and medium fast sperm clusters was observed with all three oestrogens from the lowest concentrations tested. Individual CASA (computer assisted sperm analysis) parameters of motile sperms seemed to be less sensitive indicators. This should be considered especially in toxicological research on a sperm model. Background of inconsistencies in to date published papers is discussed. The results shift the effective concentrations of ZEA, aZOL, and GEN to values achievable in vivo and raises the questions of risk assessment of these compounds in pig reproduction.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40201 - Animal and dairy science; (Animal biotechnology to be 4.4)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Czech Journal of Animal Science

ISSN

1212-1819

e-ISSN

—

Svazek periodika

62

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

435-445

Kód UT WoS článku

000410144900004

EID výsledku v databázi Scopus

2-s2.0-85029177716