In vitro antistaphylococcal synergistic effect of isoflavone metabolite demethyltexasin with amoxicillin and oxacillin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F18%3A74459" target="_blank" >RIV/60460709:41210/18:74459 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41340/18:74459

Výsledek na webu

<a href="http://dx.doi.org/10.1089/mdr.2017.0033" target="_blank" >http://dx.doi.org/10.1089/mdr.2017.0033</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1089/mdr.2017.0033" target="_blank" >10.1089/mdr.2017.0033</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In vitro antistaphylococcal synergistic effect of isoflavone metabolite demethyltexasin with amoxicillin and oxacillin

Popis výsledku v původním jazyce

Staphylococcal infections are often hard to treat due to increasing resistance, especially to beta-lactams. Previous studies described the synergy between common antibiotics and isoflavonoids. However, little is yet known about the combinatory effects of antibiotics with products of human isoflavone metabolism. In this study, demethyltexasin (DT), a human body metabolite of soybean isoflavones, was evaluated for its possible antistaphylococcal combinatory effect with amoxicillin and oxacillin. For comparison, common therapeutically used combination of amoxicillin/clavulanic acid was tested. DT showed strong synergistic interactions against most of Staphylococcus aureus strains when combined with amoxicillin and oxacillin. When oxacillin was combined with DT, resistance to this antibiotic was overcome in many cases. Moreover, antibiotic/DT combinations were effective mainly against methicillin-resistant S. aureus (MRSA). However, the commonly used drug amoxicillin/clavulanic acid was effective only ag

Název v anglickém jazyce

In vitro antistaphylococcal synergistic effect of isoflavone metabolite demethyltexasin with amoxicillin and oxacillin

Popis výsledku anglicky

Staphylococcal infections are often hard to treat due to increasing resistance, especially to beta-lactams. Previous studies described the synergy between common antibiotics and isoflavonoids. However, little is yet known about the combinatory effects of antibiotics with products of human isoflavone metabolism. In this study, demethyltexasin (DT), a human body metabolite of soybean isoflavones, was evaluated for its possible antistaphylococcal combinatory effect with amoxicillin and oxacillin. For comparison, common therapeutically used combination of amoxicillin/clavulanic acid was tested. DT showed strong synergistic interactions against most of Staphylococcus aureus strains when combined with amoxicillin and oxacillin. When oxacillin was combined with DT, resistance to this antibiotic was overcome in many cases. Moreover, antibiotic/DT combinations were effective mainly against methicillin-resistant S. aureus (MRSA). However, the commonly used drug amoxicillin/clavulanic acid was effective only ag

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

21101 - Food and beverages

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Microbial Drug Resistance

ISSN

1076-6294

e-ISSN

1931-8448

Svazek periodika

24

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

24-29

Kód UT WoS článku

000419819100004

EID výsledku v databázi Scopus

2-s2.0-85040612785