Divergent effect of fast- and slow-releasing H2S donors on boar spermatozoa under oxidative stress

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F20%3A81689" target="_blank" >RIV/60460709:41210/20:81689 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41598-020-63489-4.pdf" target="_blank" >https://www.nature.com/articles/s41598-020-63489-4.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-020-63489-4" target="_blank" >10.1038/s41598-020-63489-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Divergent effect of fast- and slow-releasing H2S donors on boar spermatozoa under oxidative stress

Popis výsledku v původním jazyce

Hydrogen sulphide H2S is involved in the physiology and pathophysiology of different cell types, but little is known about its role in sperm cells. Because of its reducing properties, we hypothesise that H2S protects spermatozoa against the deleterious effects of oxidative stress, a condition that is common to several male fertility disorders. This study aimed to determine the total antioxidant capacities of Na2S and GYY4137, which are fast and slowreleasing H2S donors, respectively, and to test whether H2S donors are able to protect spermatozoa against oxidative stress. We found that Na2S and GYY4137 show different antioxidant properties, with the total antioxidant capacity of Na2S being mostly unstable and even undetectable at 150 micromoles. Moreover, both H2S donors preserve sperm motility and reduce acrosome loss, although the effects were both dose and donor dependent. Within the range of concentrations tested 3 to 300 micromoles, GYY4137 showed positive effects on sperm motility, whereas Na2S

Název v anglickém jazyce

Divergent effect of fast- and slow-releasing H2S donors on boar spermatozoa under oxidative stress

Popis výsledku anglicky

Hydrogen sulphide H2S is involved in the physiology and pathophysiology of different cell types, but little is known about its role in sperm cells. Because of its reducing properties, we hypothesise that H2S protects spermatozoa against the deleterious effects of oxidative stress, a condition that is common to several male fertility disorders. This study aimed to determine the total antioxidant capacities of Na2S and GYY4137, which are fast and slowreleasing H2S donors, respectively, and to test whether H2S donors are able to protect spermatozoa against oxidative stress. We found that Na2S and GYY4137 show different antioxidant properties, with the total antioxidant capacity of Na2S being mostly unstable and even undetectable at 150 micromoles. Moreover, both H2S donors preserve sperm motility and reduce acrosome loss, although the effects were both dose and donor dependent. Within the range of concentrations tested 3 to 300 micromoles, GYY4137 showed positive effects on sperm motility, whereas Na2S

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10604 - Reproductive biology (medical aspects to be 3)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Svazek periodika

10

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

1-12

Kód UT WoS článku

000562145000016

EID výsledku v databázi Scopus

2-s2.0-85083478814