Can oocytes repair fragmented DNA of spermatozoa?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F20%3A84373" target="_blank" >RIV/60460709:41210/20:84373 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/20:00073194 RIV/00216224:14110/20:00116518

Výsledek na webu

<a href="https://content.sciendo.com/configurable/contentpage/journals$002facb$002f8$002f2$002farticle-p73.xml" target="_blank" >https://content.sciendo.com/configurable/contentpage/journals$002facb$002f8$002f2$002farticle-p73.xml</a>

DOI - Digital Object Identifier

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Jazyk výsledku

čeština

Název v původním jazyce

Can oocytes repair fragmented DNA of spermatozoa?

Popis výsledku v původním jazyce

Approximately half of the cases of infertility are due to male factor. In many cases the underlying cause of male infertility is not discovered and, therefore, the condition is considered idiopathic. Examination of morphology, motility, concentration and total sperm count is very important but not sufficient for complex men fertility evaluation. Sperm DNA integrity is a very important one. Sperm DNA can be fragmented by several internal or external factors. In immature sperm cells, the DNA can be repaired by reparatory mechanisms of spermatogonia or spermatocytes. However, in a haploid mature sperm cell, these fragments can not be repaired by male and the fragmented DNA is transferred to oocyte. Oocytes are able to repair male fragmented DNA after their fertilization. A quality embryo can repair damaged sperm DNA and the repair system depends on cytoplasmic and genomic quality of the oocyte. The ability of oocyte to repair sperm DNA strong depend on quality of fertilized oocytes.

Název v anglickém jazyce

Can oocytes repair fragmented DNA of spermatozoa?

Popis výsledku anglicky

Approximately half of the cases of infertility are due to male factor. In many cases the underlying cause of male infertility is not discovered and, therefore, the condition is considered idiopathic. Examination of morphology, motility, concentration and total sperm count is very important but not sufficient for complex men fertility evaluation. Sperm DNA integrity is a very important one. Sperm DNA can be fragmented by several internal or external factors. In immature sperm cells, the DNA can be repaired by reparatory mechanisms of spermatogonia or spermatocytes. However, in a haploid mature sperm cell, these fragments can not be repaired by male and the fragmented DNA is transferred to oocyte. Oocytes are able to repair male fragmented DNA after their fertilization. A quality embryo can repair damaged sperm DNA and the repair system depends on cytoplasmic and genomic quality of the oocyte. The ability of oocyte to repair sperm DNA strong depend on quality of fertilized oocytes.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

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OECD FORD obor

10604 - Reproductive biology (medical aspects to be 3)

Projekt

<a href="/cs/project/LTC18059" target="_blank" >LTC18059: Kultivační systém vhodný pro dlouhodobou kultivaci lidských folikulárních buněk</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medical Journal of Cell Biology

ISSN

2544-3577

e-ISSN

2544-3577

Svazek periodika

8

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

5

Strana od-do

73-77

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-85093648007