Wastewater-based epidemiology to assess the occurrence of new psychoactive substances and alcohol consumption in Slovakia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F20%3AN0000111" target="_blank" >RIV/60460709:41210/20:N0000111 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0147651320306011?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0147651320306011?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ecoenv.2020.110762" target="_blank" >10.1016/j.ecoenv.2020.110762</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Wastewater-based epidemiology to assess the occurrence of new psychoactive substances and alcohol consumption in Slovakia

Popis výsledku v původním jazyce

Consumption of alcohol and new psychoactive substances (NPS) in a population or during special events (music festivals) is usually monitored through individual questionnaires, forensic and toxicological data, and drug seizures. However, consumption estimates have some biases due mostly to the unknown composition of drug pills for NPS and stockpiling for alcohol. The aim of this study was to evaluate for the first time the real use of alcohol and the occurrence of NPS in Slovakia by wastewater-based epidemiology (WBE). Urban wastewater samples were collected from nine Slovak cities over two years (2017-2018) and during three music festivals. The study included about 20% of the Slovak population and 50 000 festival attendees. The urinary alcohol biomarker ethyl sulfate (EtS) and thirty NPS were analyzed by liquid chromatography tandem mass spectrometry (LC MS MS). EtS concentrations were used for estimating the per capita alcohol consumption in each city. The average alcohol consumption in the selected cities and festivals in 2017 2018 ranged between 7 and 126 L day 1000 inhabitants and increased during the weekends and music festivals. Five NPS belonging to the classes of synthetic cathinones (mephedrone, methcathinone, buphedrone and pentedrone) and phenethylamines (25 iP NBoMe) were found in the low ng L range. Methcathinone was the most frequently detected NPS, while the highest normalized mass load corresponded to mephedrone (3,1 mg day 1000 inhabitants). Wastewater based epidemiology can provide timely information on alcohol consumption and NPS occurrence at the community level that is complementary to epidemiology based monitoring techniques (e.g. population surveys, police seizures, sales statistics).

Název v anglickém jazyce

Wastewater-based epidemiology to assess the occurrence of new psychoactive substances and alcohol consumption in Slovakia

Popis výsledku anglicky

Consumption of alcohol and new psychoactive substances (NPS) in a population or during special events (music festivals) is usually monitored through individual questionnaires, forensic and toxicological data, and drug seizures. However, consumption estimates have some biases due mostly to the unknown composition of drug pills for NPS and stockpiling for alcohol. The aim of this study was to evaluate for the first time the real use of alcohol and the occurrence of NPS in Slovakia by wastewater-based epidemiology (WBE). Urban wastewater samples were collected from nine Slovak cities over two years (2017-2018) and during three music festivals. The study included about 20% of the Slovak population and 50 000 festival attendees. The urinary alcohol biomarker ethyl sulfate (EtS) and thirty NPS were analyzed by liquid chromatography tandem mass spectrometry (LC MS MS). EtS concentrations were used for estimating the per capita alcohol consumption in each city. The average alcohol consumption in the selected cities and festivals in 2017 2018 ranged between 7 and 126 L day 1000 inhabitants and increased during the weekends and music festivals. Five NPS belonging to the classes of synthetic cathinones (mephedrone, methcathinone, buphedrone and pentedrone) and phenethylamines (25 iP NBoMe) were found in the low ng L range. Methcathinone was the most frequently detected NPS, while the highest normalized mass load corresponded to mephedrone (3,1 mg day 1000 inhabitants). Wastewater based epidemiology can provide timely information on alcohol consumption and NPS occurrence at the community level that is complementary to epidemiology based monitoring techniques (e.g. population surveys, police seizures, sales statistics).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

<a href="/cs/project/EF16_019%2F0000845" target="_blank" >EF16_019/0000845: Centrum pro studium vzniku a transformací nutričně významných látek v potravním řetězci v interakci s potenciálně rizikovými látkami antropogenního původu: komplexní posouzení rizika kontaminace půdy pro kvalitu zemědělské produkce</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Ecotoxicology and Environmental Safety

ISSN

1090-2414

e-ISSN

—

Svazek periodika

200

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1-8

Kód UT WoS článku

000539092800044

EID výsledku v databázi Scopus

2-s2.0-85085025137