Antiproliferative and Cytotoxic Activities of C-Geranylated Flavonoids from Paulownia tomentosa Steud. Fruit

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F21%3A88710" target="_blank" >RIV/60460709:41210/21:88710 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14160/21:00121331

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0045206821001747?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0045206821001747?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bioorg.2021.104797" target="_blank" >10.1016/j.bioorg.2021.104797</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antiproliferative and Cytotoxic Activities of C-Geranylated Flavonoids from Paulownia tomentosa Steud. Fruit

Popis výsledku v původním jazyce

Prenylated or geranylated flavonoids have been studied for their promising antiproliferative and cytotoxic activities. Twelve natural geranylated flavonoids were isolated from the fruit of Paulownia tomentosa Steud. Their structures were elucidated using UV and IR spectroscopy, mass spectrometry, and 1D and 2D NMR spectroscopy. The absolute configurations were determined using NMR and circular dichroism. Seven of the compounds were characterized as new geranylated derivatives isolated from a natural source for the first time, namely 3-O-methyl-5-hydroxyisodiplacone, paulodiplacone A, tomentone II, tomentone B, tomentodiplacone P, paulodiplacone B, and tomentoflavone A. After 24 h of incubation at concentrations in the range 1-30 microM, the isolated compounds were tested for their antiproliferative and cytotoxic potentials against the human monocytic leukaemia cell line THP-1, using WST-1 and LDH assays, respectively. Almost all of the test compounds induced a concentration-dependent reduction in the

Název v anglickém jazyce

Antiproliferative and Cytotoxic Activities of C-Geranylated Flavonoids from Paulownia tomentosa Steud. Fruit

Popis výsledku anglicky

Prenylated or geranylated flavonoids have been studied for their promising antiproliferative and cytotoxic activities. Twelve natural geranylated flavonoids were isolated from the fruit of Paulownia tomentosa Steud. Their structures were elucidated using UV and IR spectroscopy, mass spectrometry, and 1D and 2D NMR spectroscopy. The absolute configurations were determined using NMR and circular dichroism. Seven of the compounds were characterized as new geranylated derivatives isolated from a natural source for the first time, namely 3-O-methyl-5-hydroxyisodiplacone, paulodiplacone A, tomentone II, tomentone B, tomentodiplacone P, paulodiplacone B, and tomentoflavone A. After 24 h of incubation at concentrations in the range 1-30 microM, the isolated compounds were tested for their antiproliferative and cytotoxic potentials against the human monocytic leukaemia cell line THP-1, using WST-1 and LDH assays, respectively. Almost all of the test compounds induced a concentration-dependent reduction in the

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BIOORGANIC CHEMISTRY

ISSN

0045-2068

e-ISSN

1090-2120

Svazek periodika

111

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

0-0

Kód UT WoS článku

000656969400005

EID výsledku v databázi Scopus

2-s2.0-85104613367