The mutual interaction of ferulic acid and the gut microbiota

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F25%3A102219" target="_blank" >RIV/60460709:41210/25:102219 - isvavai.cz</a>

Výsledek na webu

<a href="https://amsacta.unibo.it/id/eprint/8570/3/Book%20of%20Proceedings%201st%20INFOGUT%20ANNUAL%20MEETING%20complete%2024%2010%202025.pdf" target="_blank" >https://amsacta.unibo.it/id/eprint/8570/3/Book%20of%20Proceedings%201st%20INFOGUT%20ANNUAL%20MEETING%20complete%2024%2010%202025.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The mutual interaction of ferulic acid and the gut microbiota

Popis výsledku v původním jazyce

Interindividual variability in the metabolism of dietary polyphenols, such as ferulic acid (FA), may influence health outcomes. This study aimed to identify distinct FA metabotypes using in vitro fecal fermentation of FA with samples from 18 healthy donors, followed by 1H NMR metabolite profiling and 16S rDNA microbiome analysis. Data from both platforms were processed independently and integrated using data fusion techniques. Donors were classified based on the timing and extent of FA degradation and production of microbial catabolites. Substantial variability was observed, with distinct patterns in the formation of key metabolites, including 3-(3-hydroxyphenyl)propionic acid and dihydroferulic acid. Metabotypes differed in fecal metabolite profiles and microbial activity. For example, early FA degraders showed higher valerate and lower amino acid levels, along with a reduced abundance of Turicibacter sanguinis. These findings support the existence of reproducible FA metabotypes and suggest that gut microbiota composition plays a key role in shaping individual metabolic responses. Funding. This work was supported by the Grant Agency of the Czech Republic (GACR 23– 04655S), METROFOOD-CZ research infrastructure project (MEYS Grants LM2018100 and "COST Action CA23110 “International networking on in vitro colon models simulating gut microbiota mediated interactions (INFOGUT).

Název v anglickém jazyce

The mutual interaction of ferulic acid and the gut microbiota

Popis výsledku anglicky

Interindividual variability in the metabolism of dietary polyphenols, such as ferulic acid (FA), may influence health outcomes. This study aimed to identify distinct FA metabotypes using in vitro fecal fermentation of FA with samples from 18 healthy donors, followed by 1H NMR metabolite profiling and 16S rDNA microbiome analysis. Data from both platforms were processed independently and integrated using data fusion techniques. Donors were classified based on the timing and extent of FA degradation and production of microbial catabolites. Substantial variability was observed, with distinct patterns in the formation of key metabolites, including 3-(3-hydroxyphenyl)propionic acid and dihydroferulic acid. Metabotypes differed in fecal metabolite profiles and microbial activity. For example, early FA degraders showed higher valerate and lower amino acid levels, along with a reduced abundance of Turicibacter sanguinis. These findings support the existence of reproducible FA metabotypes and suggest that gut microbiota composition plays a key role in shaping individual metabolic responses. Funding. This work was supported by the Grant Agency of the Czech Republic (GACR 23– 04655S), METROFOOD-CZ research infrastructure project (MEYS Grants LM2018100 and "COST Action CA23110 “International networking on in vitro colon models simulating gut microbiota mediated interactions (INFOGUT).

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30308 - Nutrition, Dietetics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Book of Conference Proceedings 1 st INFOGUT Annual Meeting

ISBN

9788854972100

ISSN

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e-ISSN

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Počet stran výsledku

2

Strana od-do

91-92

Název nakladatele

University of Bologna

Místo vydání

Bologna

Místo konání akce

Bologna

Datum konání akce

1. 1. 2025

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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