The Evolutionary Landscape of Human Genome Vocabulary

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41320%2F15%3AN0000043" target="_blank" >RIV/60460709:41320/15:N0000043 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Evolutionary Landscape of Human Genome Vocabulary

Popis výsledku v původním jazyce

An inspection of the full vocabulary of the words (16-mers) of the human genome reveals that the top of the list, ranked by word occurrence, contains almost exclusively simple repeats and words from Alu sequences - the most abundant dispersed elements. These excessive words can be considered generators and suggest a simple model of genome evolution: an everlasting intrusion of the generator sequences in the neutral regions of the genome and gradual mutational changes causing an increase in sequence complexity. The way to detect the generators is to find those words all mutated forms of which appear less frequently. Examples of the generators are presented.

Název v anglickém jazyce

The Evolutionary Landscape of Human Genome Vocabulary

Popis výsledku anglicky

An inspection of the full vocabulary of the words (16-mers) of the human genome reveals that the top of the list, ranked by word occurrence, contains almost exclusively simple repeats and words from Alu sequences - the most abundant dispersed elements. These excessive words can be considered generators and suggest a simple model of genome evolution: an everlasting intrusion of the generator sequences in the neutral regions of the genome and gradual mutational changes causing an increase in sequence complexity. The way to detect the generators is to find those words all mutated forms of which appear less frequently. Examples of the generators are presented.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů