Berberine in Human Oncogenic Herpesvirus Infections and Their Linked Cancers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41330%2F21%3A87062" target="_blank" >RIV/60460709:41330/21:87062 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.3390/v13061014" target="_blank" >https://doi.org/10.3390/v13061014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/v13061014" target="_blank" >10.3390/v13061014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Berberine in Human Oncogenic Herpesvirus Infections and Their Linked Cancers

Popis výsledku v původním jazyce

Human herpesviruses are known to induce a broad spectrum of diseases, ranging from common cold sores to cancer, and infections with some types of these viruses, known as human oncogenic herpesviruses (HOHVs), can cause cancer. Challenges with viral latency, recurrent infections, and drug resistance have generated the need for finding new drugs with the ability to overcome these barriers. Berberine (BBR), a naturally occurring alkaloid, is known for its multiple biological activities, including antiviral and anticancer effects. This paper comprehensively compiles all studies that have featured anti-HOHV properties of BBR along with promising preventive effects against the associated cancers. The mechanisms and pathways induced by BBR via targeting the herpesvirus life cycle and the pathogenesis of the linked malignancies are reviewed. Approaches to enhance the therapeutic efficacy of BBR and its use in clinical practice as an anti-herpesvirus drug are also discussed.

Název v anglickém jazyce

Berberine in Human Oncogenic Herpesvirus Infections and Their Linked Cancers

Popis výsledku anglicky

Human herpesviruses are known to induce a broad spectrum of diseases, ranging from common cold sores to cancer, and infections with some types of these viruses, known as human oncogenic herpesviruses (HOHVs), can cause cancer. Challenges with viral latency, recurrent infections, and drug resistance have generated the need for finding new drugs with the ability to overcome these barriers. Berberine (BBR), a naturally occurring alkaloid, is known for its multiple biological activities, including antiviral and anticancer effects. This paper comprehensively compiles all studies that have featured anti-HOHV properties of BBR along with promising preventive effects against the associated cancers. The mechanisms and pathways induced by BBR via targeting the herpesvirus life cycle and the pathogenesis of the linked malignancies are reviewed. Approaches to enhance the therapeutic efficacy of BBR and its use in clinical practice as an anti-herpesvirus drug are also discussed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10607 - Virology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Viruses-Basel

ISSN

1999-4915

e-ISSN

1999-4915

Svazek periodika

13

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

18

Strana od-do

1-18

Kód UT WoS článku

000666015000001

EID výsledku v databázi Scopus

2-s2.0-85107413107