Origin of the Sao Paulo Yellow Fever Epidemic of 2017-2018 Revealed Through Molecular Epidemiological Analysis of Fatal Cases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41340%2F19%3A81168" target="_blank" >RIV/60460709:41340/19:81168 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41598-019-56650-1" target="_blank" >https://www.nature.com/articles/s41598-019-56650-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-019-56650-1" target="_blank" >10.1038/s41598-019-56650-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Origin of the Sao Paulo Yellow Fever Epidemic of 2017-2018 Revealed Through Molecular Epidemiological Analysis of Fatal Cases

Popis výsledku v původním jazyce

The largest outbreak of yellow fever of the 21st century in the Americas began in 2016, with intense circulation in the southeastern states of Brazil, particularly in sylvatic environments near densely populated areas including the metropolitan region of Sao Paulo city, MRSP, during 2017 and 2018. Herein, we describe the origin and molecular epidemiology of yellow fever virus, YFV, during this outbreak inferred from 36 full genome sequences taken from individuals who died following infection with zoonotic YFV. Our analysis revealed that these deaths were due to three genetic variants of sylvatic YFV that belong the South American I genotype and that were related to viruses previously isolated in 2017 from other locations in Brazil, Minas Gerais, Espirito Santo, Bahia and Rio de Janeiro states. Each variant represented an independent virus introduction into the MRSP. Phylogeographic and geopositioning analyses suggested that the virus moved around the peri urban area without detectable human to human

Název v anglickém jazyce

Origin of the Sao Paulo Yellow Fever Epidemic of 2017-2018 Revealed Through Molecular Epidemiological Analysis of Fatal Cases

Popis výsledku anglicky

The largest outbreak of yellow fever of the 21st century in the Americas began in 2016, with intense circulation in the southeastern states of Brazil, particularly in sylvatic environments near densely populated areas including the metropolitan region of Sao Paulo city, MRSP, during 2017 and 2018. Herein, we describe the origin and molecular epidemiology of yellow fever virus, YFV, during this outbreak inferred from 36 full genome sequences taken from individuals who died following infection with zoonotic YFV. Our analysis revealed that these deaths were due to three genetic variants of sylvatic YFV that belong the South American I genotype and that were related to viruses previously isolated in 2017 from other locations in Brazil, Minas Gerais, Espirito Santo, Bahia and Rio de Janeiro states. Each variant represented an independent virus introduction into the MRSP. Phylogeographic and geopositioning analyses suggested that the virus moved around the peri urban area without detectable human to human

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10607 - Virology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Svazek periodika

9

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

1-10

Kód UT WoS článku

000508985300039

EID výsledku v databázi Scopus

2-s2.0-85077209331