Increased Mutation Rate Is Linked to Genome Reduction in Prokaryotes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41340%2F20%3A84613" target="_blank" >RIV/60460709:41340/20:84613 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubmed.ncbi.nlm.nih.gov/32763167/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/32763167/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cub.2020.07.034" target="_blank" >10.1016/j.cub.2020.07.034</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increased Mutation Rate Is Linked to Genome Reduction in Prokaryotes

Popis výsledku v původním jazyce

The evolutionary processes that drive variation in genome size across the tree of life remain unresolved. Effective population size (N-e) is thought to play an important role in shaping genome size 1-3-a key example being the reduced genomes of insect endosymbionts, which undergo population bottlenecks during transmission 4. However, the existence of reduced genomes in marine and terrestrial prokaryote species with large N-e indicate that genome reduction is influenced by multiple processes 3. One candidate process is enhanced mutation rate, which can increase adaptive capacity but can also promote gene loss. To investigate evolutionary forces associated with prokaryotic genome reduction, we performed molecular evolutionary and phylogenomic analyses of nine lineages from five bacterial and archaeal phyla. We found that gene-loss rate strongly correlated with synonymous substitution rate (a proxy for mutation rate) in seven of the nine lineages. However, gene-loss rate showed weak or no correlation wi

Název v anglickém jazyce

Increased Mutation Rate Is Linked to Genome Reduction in Prokaryotes

Popis výsledku anglicky

The evolutionary processes that drive variation in genome size across the tree of life remain unresolved. Effective population size (N-e) is thought to play an important role in shaping genome size 1-3-a key example being the reduced genomes of insect endosymbionts, which undergo population bottlenecks during transmission 4. However, the existence of reduced genomes in marine and terrestrial prokaryote species with large N-e indicate that genome reduction is influenced by multiple processes 3. One candidate process is enhanced mutation rate, which can increase adaptive capacity but can also promote gene loss. To investigate evolutionary forces associated with prokaryotic genome reduction, we performed molecular evolutionary and phylogenomic analyses of nine lineages from five bacterial and archaeal phyla. We found that gene-loss rate strongly correlated with synonymous substitution rate (a proxy for mutation rate) in seven of the nine lineages. However, gene-loss rate showed weak or no correlation wi

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CURRENT BIOLOGY

ISSN

0960-9822

e-ISSN

1879-0445

Svazek periodika

30

Číslo periodika v rámci svazku

19

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

13

Strana od-do

1-13

Kód UT WoS článku

000579845200053

EID výsledku v databázi Scopus

2-s2.0-85090059476