Design, syntéza a studium modelu fotolyasy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F04%3A00011790" target="_blank" >RIV/60461373:22310/04:00011790 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model

Popis výsledku v původním jazyce

Two new artificial photolyase models that recognize pyrimidine dimers in protic and aprotic organic solvents as well as in water through a combination of charge and hydrogen bonding interactions and use a mimic of the flavine to achieve repair through reductive photoinduced electron transfer are presented. Flourescence and NMR titration studies show that it forms a 1:1 complex with pyrimidine dimers with binding constants of ~103 M-1 in acetonitrile or methanol, while binding constants in water at pH7.2are slightly lower. Excitation of the complex with visible light leads to clean and rapid cycloreversion of the pyrimidine dimer through photoinduced electron transfer catalysis. The reaction in water is significantly faster than in organic solvents. The reaction slows down at higher conversions due to product inhibition.

Název v anglickém jazyce

Design, Synthesis and Evaluation of a Biomimetic Artificial Photolyase Model

Popis výsledku anglicky

Two new artificial photolyase models that recognize pyrimidine dimers in protic and aprotic organic solvents as well as in water through a combination of charge and hydrogen bonding interactions and use a mimic of the flavine to achieve repair through reductive photoinduced electron transfer are presented. Flourescence and NMR titration studies show that it forms a 1:1 complex with pyrimidine dimers with binding constants of ~103 M-1 in acetonitrile or methanol, while binding constants in water at pH7.2are slightly lower. Excitation of the complex with visible light leads to clean and rapid cycloreversion of the pyrimidine dimer through photoinduced electron transfer catalysis. The reaction in water is significantly faster than in organic solvents. The reaction slows down at higher conversions due to product inhibition.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Organic Chemistry

ISSN

0022-3263

e-ISSN

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Svazek periodika

69

Číslo periodika v rámci svazku

24

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

3

Strana od-do

8183-8185

Kód UT WoS článku

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EID výsledku v databázi Scopus

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