Inherently Electroactive Graphene Oxide Nanoplatelets As Labels for Single Nucleotide Polymorphism Detection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F12%3A43893564" target="_blank" >RIV/60461373:22310/12:43893564 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1021/nn301359y" target="_blank" >http://dx.doi.org/10.1021/nn301359y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/nn301359y" target="_blank" >10.1021/nn301359y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Inherently Electroactive Graphene Oxide Nanoplatelets As Labels for Single Nucleotide Polymorphism Detection

Popis výsledku v původním jazyce

Graphene materials are being widely used in electrochemistry due to their versatility and excellent properties as platforms for biosensing. However, no records show the use of inherent redox properties of graphene oxide as a label for detection. Here forthe first time we used graphene oxide nanoplatelets (GONPs) as electroactive labels for DNA analysis. The working signal comes from the reduction of he oxygen-containing groups present on the surface of GONPs. The different ability of the graphene oxidenanoplatelets to conjugate to DNA hybrids obtained with complementary, noncomplementary, and one-mismatch sequences allows the discrimination of single-nucleotide polymorphism correlated with Alzheimer's disease. We believe that our findings are very important to open a new route in the use of graphene oxide in electrochemistry.

Název v anglickém jazyce

Inherently Electroactive Graphene Oxide Nanoplatelets As Labels for Single Nucleotide Polymorphism Detection

Popis výsledku anglicky

Graphene materials are being widely used in electrochemistry due to their versatility and excellent properties as platforms for biosensing. However, no records show the use of inherent redox properties of graphene oxide as a label for detection. Here forthe first time we used graphene oxide nanoplatelets (GONPs) as electroactive labels for DNA analysis. The working signal comes from the reduction of he oxygen-containing groups present on the surface of GONPs. The different ability of the graphene oxidenanoplatelets to conjugate to DNA hybrids obtained with complementary, noncomplementary, and one-mismatch sequences allows the discrimination of single-nucleotide polymorphism correlated with Alzheimer's disease. We believe that our findings are very important to open a new route in the use of graphene oxide in electrochemistry.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Nano

ISSN

1936-0851

e-ISSN

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Svazek periodika

64

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

8546-8551

Kód UT WoS článku

000310096100011

EID výsledku v databázi Scopus

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