A new way of solid dosage form samples preparation for SEM and FTIR using microtome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F13%3A43895356" target="_blank" >RIV/60461373:22310/13:43895356 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3109/10837450.2013.788515" target="_blank" >http://dx.doi.org/10.3109/10837450.2013.788515</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/10837450.2013.788515" target="_blank" >10.3109/10837450.2013.788515</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A new way of solid dosage form samples preparation for SEM and FTIR using microtome

Popis výsledku v původním jazyce

Rapid and correct production of generic solid dosage forms requires a large amount of analytical data and conclusions. Modern analytical techniques have a good resolution and accuray and allow obtaining a lot of information about the original products. Scanning electron microscopy (SEM) is used for observation infrared (FTIR) spectroscopy mapping allows determining the distribution and characterization of individual components in a solid dosage form. However, the samples prepared by common way, using scalpel or tablet splitter, are not good enough. It was the reason for development of a new and better method of sample preparation, which uses microtome. Well-prepared samples analyzed by SEM and FTIR mapping allow to determine a solid dosage form formulation, excipient content and distribution of excipient and active pharmaceutical ingredient.

Název v anglickém jazyce

A new way of solid dosage form samples preparation for SEM and FTIR using microtome

Popis výsledku anglicky

Rapid and correct production of generic solid dosage forms requires a large amount of analytical data and conclusions. Modern analytical techniques have a good resolution and accuray and allow obtaining a lot of information about the original products. Scanning electron microscopy (SEM) is used for observation infrared (FTIR) spectroscopy mapping allows determining the distribution and characterization of individual components in a solid dosage form. However, the samples prepared by common way, using scalpel or tablet splitter, are not good enough. It was the reason for development of a new and better method of sample preparation, which uses microtome. Well-prepared samples analyzed by SEM and FTIR mapping allow to determine a solid dosage form formulation, excipient content and distribution of excipient and active pharmaceutical ingredient.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pharmaceutical Development and Technology

ISSN

1083-7450

e-ISSN

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Svazek periodika

19

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

411-416

Kód UT WoS článku

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EID výsledku v databázi Scopus

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